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Abstract
Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.
Methods: Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.
Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.
Significance: Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.
Methods: Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.
Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.
Significance: Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.
| Original language | English |
|---|---|
| Pages (from-to) | 1310-1317 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 64 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2017 |
Subject classification (UKÄ)
- Control Engineering
- Anesthesiology and Intensive Care
- Other Medical Engineering
Free keywords
- Drug delivery, Medical control systems
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Hemodynamic Stabilization
Soltesz, K. (PI), Sjöberg, T. (Researcher), Paskevicius, A. (Researcher), Pigot, H. (Research student), Wahlquist, Y. (Researcher) & Sturk, C. (Researcher)
Swedish Government Agency for Innovation Systems (Vinnova), Swedish Research Council
2016/09/01 → 2023/12/31
Project: Research