Abstract
Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.
Original language | English |
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Pages (from-to) | 133-143 |
Number of pages | 11 |
Journal | The Lancet Child and Adolescent Health |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2018 Feb |
Subject classification (UKÄ)
- Endocrinology and Diabetes