TY - JOUR
T1 - Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma
T2 - results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
AU - Zamora-Ros, Raul
AU - Alghamdi, Muath A.
AU - Cayssials, Valerie
AU - Franceschi, Silvia
AU - Almquist, Martin
AU - Hennings, Joakim
AU - Sandström, Maria
AU - Tsilidis, Konstantinos K.
AU - Weiderpass, Elisabete
AU - Boutron-Ruault, Marie Christine
AU - Hammer Bech, Bodil
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Petersen, Kristina E.N.
AU - Mancini, Francesca Romana
AU - Mahamat-Saleh, Yahya
AU - Bonnet, Fabrice
AU - Kühn, Tilman
AU - Fortner, Renée T.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Martimianaki, Georgia
AU - Masala, Giovanna
AU - Grioni, Sara
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Fasanelli, Francesca
AU - Skeie, Guri
AU - Braaten, Tonje
AU - Lasheras, Cristina
AU - Salamanca-Fernández, Elena
AU - Amiano, Pilar
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Manjer, Jonas
AU - Wallström, Peter
AU - Bueno-de-Mesquita, H. Bas
AU - Peeters, Petra H.
AU - Khaw, Kay Thee
AU - Wareham, Nicholas J.
AU - Schmidt, Julie A.
AU - Aune, Dagfinn
AU - Byrnes, Graham
AU - Scalbert, Augustin
AU - Agudo, Antonio
AU - Rinaldi, Sabina
PY - 2019/12
Y1 - 2019/12
N2 - Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.
AB - Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.
KW - Coffee
KW - Cohort
KW - EPIC
KW - Intake
KW - Tea
KW - Thyroid cancer
U2 - 10.1007/s00394-018-1874-z
DO - 10.1007/s00394-018-1874-z
M3 - Article
C2 - 30535794
AN - SCOPUS:85058140798
SN - 1436-6207
VL - 58
SP - 3303
EP - 3312
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 8
ER -
