Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: A population-based case-control study

B. Rasouli, E. Ahlqvist, L. Alfredsson, T. Andersson, P. O. Carlsson, L. Groop, J. E. Löfvenborg, M. Martinell, A. Rosengren, T. Tuomi, A. Wolk, S. Carlsson

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results: Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370). Conclusion: Our findings suggest that coffee consumption interacts with HLA to promote LADA.

Original languageEnglish
Pages (from-to)354-360
JournalDiabetes & Metabolism
Volume44
Issue number4
Early online date2018 May 17
DOIs
Publication statusPublished - 2018 Sep

Subject classification (UKÄ)

  • Endocrinology and Diabetes
  • Nutrition and Dietetics

Keywords

  • Autoimmune diabetes
  • Coffee consumption
  • Gene–environmental interaction
  • LADA
  • Latent autoimmune diabetes in adults
  • Type 2 diabetes
  • ANDIS
  • diabetes
  • diabetics

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