Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Nils Landegren; Lindsey B. Rosen; Eva Freyhult; Daniel Eriksson; Tove Fall; Gustav Smith; Elise M.N. Ferre; Petter Brodin; Donald Sharon; Michael Snyder; Michail Lionakis; Mark Anderson; Olle Kämpe

doi:10.7554/eLife.43578

Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Nils Landegren, Lindsey B. Rosen, Eva Freyhult, Daniel Eriksson, Tove Fall, Gustav Smith, Elise M.N. Ferre, Petter Brodin, Donald Sharon, Michael Snyder, Michail Lionakis, Mark Anderson, Olle Kämpe

Research output: Contribution to journal › Article › peer-review

Abstract

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

Original language	English
Article number	e43578
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.43578
Publication status	Published - 2019 Jun 27

Subject classification (UKÄ)

Endocrinology and Diabetes
Immunology in the Medical Area (including Cell and Immunotherapy)

Free keywords

APS1/APECED
autoantibody
autoantigen
human
human biology
immune tolerance
immunology
inflammation
medicine
type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.7554/eLife.43578Licence: CC0

Cite this

@article{8c5df12c1262404a95f4304007b5d2ee,

title = "Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'",

abstract = "The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.",

keywords = "APS1/APECED, autoantibody, autoantigen, human, human biology, immune tolerance, immunology, inflammation, medicine, type 1 diabetes",

author = "Nils Landegren and Rosen, \{Lindsey B.\} and Eva Freyhult and Daniel Eriksson and Tove Fall and Gustav Smith and Ferre, \{Elise M.N.\} and Petter Brodin and Donald Sharon and Michael Snyder and Michail Lionakis and Mark Anderson and Olle K{\"a}mpe",

year = "2019",

month = jun,

day = "27",

doi = "10.7554/eLife.43578",

language = "English",

volume = "8",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

AU - Landegren, Nils

AU - Rosen, Lindsey B.

AU - Freyhult, Eva

AU - Eriksson, Daniel

AU - Fall, Tove

AU - Smith, Gustav

AU - Ferre, Elise M.N.

AU - Brodin, Petter

AU - Sharon, Donald

AU - Snyder, Michael

AU - Lionakis, Michail

AU - Anderson, Mark

AU - Kämpe, Olle

PY - 2019/6/27

Y1 - 2019/6/27

N2 - The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

AB - The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

KW - APS1/APECED

KW - autoantibody

KW - autoantigen

KW - human

KW - human biology

KW - immune tolerance

KW - immunology

KW - inflammation

KW - medicine

KW - type 1 diabetes

UR - https://www.scopus.com/pages/publications/85068819205

U2 - 10.7554/eLife.43578

DO - 10.7554/eLife.43578

M3 - Article

C2 - 31244471

AN - SCOPUS:85068819205

SN - 2050-084X

VL - 8

JO - eLife

JF - eLife

M1 - e43578

ER -

Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this