Common sequence variants on 20q11.22 confer melanoma susceptibility

Kevin M. Brown; Stuart MacGregor; Grant W. Montgomery; David W. Craig; Zhen Zhen Zhao; Kelly Iyadurai; Anjali K. Henders; Nils Homer; Megan J. Campbell; Mitchell Stark; Shane Thomas; Helen Schmid; Elizabeth A. Holland; Elizabeth M. Gillanders; David L. Duffy; Judith A. Maskiell; Jodie Jetann; Megan Ferguson; Dietrich A. Stephan; Anne E. Cust; David Whiteman; Adele Green; Håkan Olsson; Susana Puig; Paola Ghiorzo; Johan Hansson; Florence Demenais; Alisa M. Goldstein; Nelleke A. Gruis; David E. Elder; Julia Newton Bishop; Richard F. Kefford; Graham G. Giles; Bruce K. Armstrong; Joanne F. Aitken; John L. Hopper; Nicholas G. Martin; Jeffrey M. Trent; Graham J. Mann; Nicholas K. Hayward

doi:10.1038/ng.163

Common sequence variants on 20q11.22 confer melanoma susceptibility

Kevin M. Brown, Stuart MacGregor, Grant W. Montgomery, David W. Craig, Zhen Zhen Zhao, Kelly Iyadurai, Anjali K. Henders, Nils Homer, Megan J. Campbell, Mitchell Stark, Shane Thomas, Helen Schmid, Elizabeth A. Holland, Elizabeth M. Gillanders, David L. Duffy, Judith A. Maskiell, Jodie Jetann, Megan Ferguson, Dietrich A. Stephan, Anne E. CustDavid Whiteman, Adele Green, Håkan Olsson, Susana Puig, Paola Ghiorzo, Johan Hansson, Florence Demenais, Alisa M. Goldstein, Nelleke A. Gruis, David E. Elder, Julia Newton Bishop, Richard F. Kefford, Graham G. Giles, Bruce K. Armstrong, Joanne F. Aitken, John L. Hopper, Nicholas G. Martin, Jeffrey M. Trent, Graham J. Mann, Nicholas K. Hayward

Breastcancer-genetics

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

Original language	English
Pages (from-to)	838-840
Journal	Nature Genetics
Volume	40
Issue number	7
DOIs	https://doi.org/10.1038/ng.163
Publication status	Published - 2008

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.163

Cite this

Brown, K. M., MacGregor, S., Montgomery, G. W., Craig, D. W., Zhao, Z. Z., Iyadurai, K., Henders, A. K., Homer, N., Campbell, M. J., Stark, M., Thomas, S., Schmid, H., Holland, E. A., Gillanders, E. M., Duffy, D. L., Maskiell, J. A., Jetann, J., Ferguson, M., Stephan, D. A., ... Hayward, N. K. (2008). Common sequence variants on 20q11.22 confer melanoma susceptibility. Nature Genetics, 40(7), 838-840. https://doi.org/10.1038/ng.163

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title = "Common sequence variants on 20q11.22 confer melanoma susceptibility",

abstract = "We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.",

author = "Brown, {Kevin M.} and Stuart MacGregor and Montgomery, {Grant W.} and Craig, {David W.} and Zhao, {Zhen Zhen} and Kelly Iyadurai and Henders, {Anjali K.} and Nils Homer and Campbell, {Megan J.} and Mitchell Stark and Shane Thomas and Helen Schmid and Holland, {Elizabeth A.} and Gillanders, {Elizabeth M.} and Duffy, {David L.} and Maskiell, {Judith A.} and Jodie Jetann and Megan Ferguson and Stephan, {Dietrich A.} and Cust, {Anne E.} and David Whiteman and Adele Green and H{\aa}kan Olsson and Susana Puig and Paola Ghiorzo and Johan Hansson and Florence Demenais and Goldstein, {Alisa M.} and Gruis, {Nelleke A.} and Elder, {David E.} and Bishop, {Julia Newton} and Kefford, {Richard F.} and Giles, {Graham G.} and Armstrong, {Bruce K.} and Aitken, {Joanne F.} and Hopper, {John L.} and Martin, {Nicholas G.} and Trent, {Jeffrey M.} and Mann, {Graham J.} and Hayward, {Nicholas K.}",

year = "2008",

doi = "10.1038/ng.163",

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journal = "Nature Genetics",

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Brown, KM, MacGregor, S, Montgomery, GW, Craig, DW, Zhao, ZZ, Iyadurai, K, Henders, AK, Homer, N, Campbell, MJ, Stark, M, Thomas, S, Schmid, H, Holland, EA, Gillanders, EM, Duffy, DL, Maskiell, JA, Jetann, J, Ferguson, M, Stephan, DA, Cust, AE, Whiteman, D, Green, A, Olsson, H, Puig, S, Ghiorzo, P, Hansson, J, Demenais, F, Goldstein, AM, Gruis, NA, Elder, DE, Bishop, JN, Kefford, RF, Giles, GG, Armstrong, BK, Aitken, JF, Hopper, JL, Martin, NG, Trent, JM, Mann, GJ & Hayward, NK 2008, 'Common sequence variants on 20q11.22 confer melanoma susceptibility', Nature Genetics, vol. 40, no. 7, pp. 838-840. https://doi.org/10.1038/ng.163

TY - JOUR

T1 - Common sequence variants on 20q11.22 confer melanoma susceptibility

AU - Brown, Kevin M.

AU - MacGregor, Stuart

AU - Montgomery, Grant W.

AU - Craig, David W.

AU - Zhao, Zhen Zhen

AU - Iyadurai, Kelly

AU - Henders, Anjali K.

AU - Homer, Nils

AU - Campbell, Megan J.

AU - Stark, Mitchell

AU - Thomas, Shane

AU - Schmid, Helen

AU - Holland, Elizabeth A.

AU - Gillanders, Elizabeth M.

AU - Duffy, David L.

AU - Maskiell, Judith A.

AU - Jetann, Jodie

AU - Ferguson, Megan

AU - Stephan, Dietrich A.

AU - Cust, Anne E.

AU - Whiteman, David

AU - Green, Adele

AU - Olsson, Håkan

AU - Puig, Susana

AU - Ghiorzo, Paola

AU - Hansson, Johan

AU - Demenais, Florence

AU - Goldstein, Alisa M.

AU - Gruis, Nelleke A.

AU - Elder, David E.

AU - Bishop, Julia Newton

AU - Kefford, Richard F.

AU - Giles, Graham G.

AU - Armstrong, Bruce K.

AU - Aitken, Joanne F.

AU - Hopper, John L.

AU - Martin, Nicholas G.

AU - Trent, Jeffrey M.

AU - Mann, Graham J.

AU - Hayward, Nicholas K.

PY - 2008

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N2 - We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

AB - We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

U2 - 10.1038/ng.163

DO - 10.1038/ng.163

M3 - Article

C2 - 18488026

SN - 1546-1718

VL - 40

SP - 838

EP - 840

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -