Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

Peter Broderick, Daniel Chubb, David C. Johnson, Niels Weinhold, Asta Foersti, Amy Lloyd, Bianca Olver, Yussanne P. Ma, Sara E. Dobbins, Brian A. Walker, Faith E. Davies, Walter A. Gregory, J. Anthony Child, Fiona M. Ross, Graham H. Jackson, Kai Neben, Anna Jauch, Per Hoffmann, Thomas W. Muehleisen, Markus M. NoethenSusanne Moebus, Ian P. Tomlinson, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan, Richard S. Houlston

Research output: Contribution to journalArticlepeer-review


To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
Original languageEnglish
Pages (from-to)58-U83
JournalNature Genetics
Issue number1
Publication statusPublished - 2012

Subject classification (UKÄ)

  • Public Health, Global Health, Social Medicine and Epidemiology


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