Abstract
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
Original language | English |
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Pages (from-to) | 58-U83 |
Journal | Nature Genetics |
Volume | 44 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2012 |
Subject classification (UKÄ)
- Public Health, Global Health, Social Medicine and Epidemiology