Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver

P. H. Möller, K. Ivarsson, U. Stenram, M. Radnell, K. G. Tranberg

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was transplanted (implanted if not stated otherwise) into the left lateral lobe of the rat liver, and treatment was performed 8 days later. In the main experiment, rats were treated with resection of the tumour-bearing robe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection of the tumour-bearing lobe, with no difference in local control. Metastatic spread after resection of the median liver robe was similar to that observed after sham procedures for thermotherapy or resection, suggesting that the advantage of thermotherapy was not due to a difference in surgical trauma. Additional studies showed that laser thermotherapy reduced intraperitoneal spread when treatment was suboptimal or in a tumour inoculation model and suggested that immunological mechanisms might be involved. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour compared with resection.

Original languageEnglish
Pages (from-to)1884-1892
JournalBritish Journal of Cancer
Volume77
Issue number11
DOIs
Publication statusPublished - 1998 Jun 1

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • Laser
  • Liver
  • Neoplasm
  • Resection
  • Thermotherapy

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