TY - JOUR
T1 - Comparison of in vitro methods of measuring mucoadhesion: Ellipsometry, tensile strength and rheological measurements.
AU - Ivarsson, David
AU - Wahlgren, Marie
PY - 2012
Y1 - 2012
N2 - In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing good mucoadhesion with the ellipsometry method. No two methods gave the same ranking of mucoadhesive strength of the polymers. The conflicting results obtained with the different methods underline the need for further improvements in existing experimental techniques and theoretical concepts for the correct assessment of mucoadhesive properties.
AB - In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing good mucoadhesion with the ellipsometry method. No two methods gave the same ranking of mucoadhesive strength of the polymers. The conflicting results obtained with the different methods underline the need for further improvements in existing experimental techniques and theoretical concepts for the correct assessment of mucoadhesive properties.
U2 - 10.1016/j.colsurfb.2011.12.020
DO - 10.1016/j.colsurfb.2011.12.020
M3 - Article
C2 - 22209653
SN - 1873-4367
VL - 92
SP - 353
EP - 359
JO - Colloids and Surfaces. B, Biointerfaces
JF - Colloids and Surfaces. B, Biointerfaces
ER -