Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases

Halla Vidarsdottir; Lena Tran; Björn Nodin; Karin Jirström; Maria Planck; Johanna S.M. Mattsson; Johan Botling; Patrick Micke; Per Jönsson; Hans Brunnström

doi:10.1093/ajcp/aqy083

Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases

Halla Vidarsdottir, Lena Tran, Björn Nodin, Karin Jirström, Maria Planck, Johanna S.M. Mattsson, Johan Botling, Patrick Micke, Per Jönsson, Hans Brunnström

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.

Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.

Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.

Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.

Original language	English
Pages (from-to)	533-544
Number of pages	12
Journal	American Journal of Clinical Pathology
Volume	150
Issue number	6
DOIs	https://doi.org/10.1093/ajcp/aqy083
Publication status	Published - 2018

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcp/aqy083

1 Doctoral Thesis (compilation)

Lung Metastases - Diagnostic, Prognostic and Molecular Aspects with Focus on Colorectal Cancer
Vidarsdottir, H., 2021, Lund: Lund University, Faculty of Medicine. 114 p.
Research output: Thesis › Doctoral Thesis (compilation)

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Histopathological and molecular diagnostics of lung cancer
Brunnström, H. (PI) & Malmros, K. (Researcher)
Mrs. Berta Kamprad's Cancer Foundation, Cancerfonden, Gunnar Nilssons cancerstiftelse
2011/08/15 → …
Project: Research

Cite this

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title = "Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases",

abstract = "Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.",

author = "Halla Vidarsdottir and Lena Tran and Bj{\"o}rn Nodin and Karin Jirstr{\"o}m and Maria Planck and Mattsson, {Johanna S.M.} and Johan Botling and Patrick Micke and Per J{\"o}nsson and Hans Brunnstr{\"o}m",

year = "2018",

doi = "10.1093/ajcp/aqy083",

language = "English",

volume = "150",

pages = "533--544",

journal = "American Journal of Clinical Pathology",

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T1 - Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases

AU - Vidarsdottir, Halla

AU - Tran, Lena

AU - Nodin, Björn

AU - Jirström, Karin

AU - Planck, Maria

AU - Mattsson, Johanna S.M.

AU - Botling, Johan

AU - Micke, Patrick

AU - Jönsson, Per

AU - Brunnström, Hans

PY - 2018

Y1 - 2018

N2 - Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.

AB - Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.

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DO - 10.1093/ajcp/aqy083

M3 - Article

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SN - 1943-7722

VL - 150

SP - 533

EP - 544

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

IS - 6

ER -

Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Lung Metastases - Diagnostic, Prognostic and Molecular Aspects with Focus on Colorectal Cancer

Projects

Histopathological and molecular diagnostics of lung cancer

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