Complexation between antimicrobial peptides and polyelectrolytes

Bruno C. Borro, Martin Malmsten

Research output: Contribution to journalReview articlepeer-review

Abstract

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for AMP-polyelectrolyte nanoparticle formation, as well as for AMP incorporation in polyelectrolyte microgels and multilayer structures, and consequences of these for functional performance exemplified.

Original languageEnglish
Pages (from-to)251-260
Number of pages10
JournalAdvances in Colloid and Interface Science
Volume270
Early online date2019 Aug
DOIs
Publication statusPublished - 2019

Subject classification (UKÄ)

  • Other Engineering and Technologies not elsewhere specified
  • Other Chemistry Topics

Free keywords

  • Antimicrobial peptide
  • Complex
  • Microgel
  • Multilayer
  • Polyelectrolyte

Fingerprint

Dive into the research topics of 'Complexation between antimicrobial peptides and polyelectrolytes'. Together they form a unique fingerprint.

Cite this