Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

Piero Pollesello; Martti Ovaska; J. Tenhunen; J. Vidgren; Marjo Yliperttula; Carola Tilgmann; T. Lotta; Juha Kaivola

Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

Piero Pollesello (Inventor), Martti Ovaska (Inventor), J. Tenhunen (Inventor), J. Vidgren (Inventor), Marjo Yliperttula (Inventor), Carola Tilgmann (Inventor), T. Lotta (Inventor), Juha Kaivola (Inventor)

Orion Corporation

Research output: Patent

Abstract

This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban

Original language	English
Patent number	US 6774103 B1
IPC	514-9
Priority date	1997/09/24
Publication status	Published - 2004 Aug 10
Externally published	Yes

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease
Other Chemical Engineering

Free keywords

calcium-ATPase
phospholamban
drug discovery

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abstract = "This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban",

keywords = "calcium-ATPase, phospholamban, drug discovery",

author = "Piero Pollesello and Martti Ovaska and J. Tenhunen and J. Vidgren and Marjo Yliperttula and Carola Tilgmann and T. Lotta and Juha Kaivola",

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T1 - Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

AU - Pollesello, Piero

AU - Ovaska, Martti

AU - Tenhunen, J.

AU - Vidgren, J.

AU - Yliperttula, Marjo

AU - Tilgmann, Carola

AU - Lotta, T.

AU - Kaivola, Juha

PY - 2004/8/10

Y1 - 2004/8/10

N2 - This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban

AB - This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban

KW - calcium-ATPase

KW - phospholamban

KW - drug discovery

M3 - Patent

M1 - US 6774103 B1

ER -

Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

Abstract

Subject classification (UKÄ)

Free keywords

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Cite this