Computational Perspectives on Neuromodulation of Aging

Research output: Contribution to journalReview articlepeer-review


Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.
Original languageEnglish
Pages (from-to)513-518
JournalActa Neurochirurgica. Supplementum
Publication statusPublished - 2007

Subject classification (UKÄ)

  • Psychology (excluding Applied Psychology)

Free keywords

  • cognitive functions
  • neural networks
  • aging
  • neuromodulation
  • Dopamine
  • noise


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