Computational Perspectives on Neuromodulation of Aging

Sverker Sikström

doi:10.1007/978-3-211-33081-4

Computational Perspectives on Neuromodulation of Aging

Sverker Sikström

Cognitive Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.

Original language	English
Pages (from-to)	513-518
Journal	Acta Neurochirurgica. Supplementum
Volume	97
DOIs	https://doi.org/10.1007/978-3-211-33081-4
Publication status	Published - 2007

Subject classification (UKÄ)

Psychology (excluding Applied Psychology)

Free keywords

cognitive functions
neural networks
aging
neuromodulation
Dopamine
noise

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10.1007/978-3-211-33081-4

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title = "Computational Perspectives on Neuromodulation of Aging",

abstract = "Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.",

keywords = "cognitive functions, neural networks, aging, neuromodulation, Dopamine, noise",

author = "Sverker Sikstr{\"o}m",

year = "2007",

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language = "English",

volume = "97",

pages = "513--518",

journal = "Acta Neurochirurgica. Supplementum",

issn = "0065-1419",

publisher = "Springer Science and Business Media B.V.",

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T1 - Computational Perspectives on Neuromodulation of Aging

AU - Sikström, Sverker

PY - 2007

Y1 - 2007

N2 - Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.

AB - Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.

KW - cognitive functions

KW - neural networks

KW - aging

KW - neuromodulation

KW - Dopamine

KW - noise

U2 - 10.1007/978-3-211-33081-4

DO - 10.1007/978-3-211-33081-4

M3 - Review article

SN - 0065-1419

VL - 97

SP - 513

EP - 518

JO - Acta Neurochirurgica. Supplementum

JF - Acta Neurochirurgica. Supplementum

ER -

Computational Perspectives on Neuromodulation of Aging

Abstract

Subject classification (UKÄ)

Free keywords

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