Concentrates of buttermilk and krill oil improve cognition in aged rats

Alba García-Serrano, Joao Tomé-Carneiro, M. Carmen Crespo, M. Visitación Calvo, Inmaculada Pereda-Pérez, Shishir Baliyan, Emma Burgos-Ramos, Olimpio Montero, Alberto Dávalos, César Venero, Francesco Visioli, Javier Fontecha

Research output: Contribution to journalArticlepeer-review

6 Citations (SciVal)


Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with concentrates of polar lipids from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements, calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty acids, on cognitive decline.

Original languageEnglish
Article number102077
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Publication statusPublished - 2020 Apr 1
Externally publishedYes

Subject classification (UKÄ)

  • Basic Medicine


  • Aging
  • Behavior
  • Cognitive decline
  • Functional foods
  • Milk
  • Nutraceuticals
  • Omega 3 fatty acids
  • Phospholipids


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