Abstract
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
| Original language | English |
|---|---|
| Pages (from-to) | 791-795 |
| Journal | British Journal of Nutrition |
| Volume | 94 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012), Experimental Cardiovascular Research Unit (013242110)
Subject classification (UKÄ)
- Nutrition and Dietetics
Free keywords
- tumour necrosis
- conjugated linoleic acid
- C-reactive protein
- inflammation
- factor-alpha