Abstract
Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.
| Original language | English |
|---|---|
| Pages (from-to) | 141-145 |
| Journal | Contact Dermatitis |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
Subject classification (UKÄ)
- Dermatology and Venereal Diseases
Free keywords
- Bioban P 1487
- CAS 2224-44-4
- CAS 1854-23-5
- allergic contact dermatitis
- delayed hypersensitivity
- 4
- 4'-(2-ethyl-2-nitro-1
- 3-propanediyl)-bis morpholine
- high-performance liquid chromatography
- metal working fluids
- 4-(2-nitrobutyl)-morpholine
- preservatives
- occupational
- engineering industry