Contact allergy to the active ingredients of Bioban P 1487

Birgitta Gruvberger, Magnus Bruze, Erik Zimerson

Research output: Contribution to journalArticlepeer-review


Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.
Original languageEnglish
Pages (from-to)141-145
JournalContact Dermatitis
Issue number3
Publication statusPublished - 1996

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Free keywords

  • Bioban P 1487
  • CAS 2224-44-4
  • CAS 1854-23-5
  • allergic contact dermatitis
  • delayed hypersensitivity
  • 4
  • 4'-(2-ethyl-2-nitro-1
  • 3-propanediyl)-bis morpholine
  • high-performance liquid chromatography
  • metal working fluids
  • 4-(2-nitrobutyl)-morpholine
  • preservatives
  • occupational
  • engineering industry


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