Contact dermatitis caused by a new rubber compound detected in canvas shoes

Eva Hulstaert; Ola Bergendorff; Christina Persson; An Goossens; Liesbeth Gilissen; Malin Engfeldt; Magnus Bruze; Marie L Schuttelaar; Joost M Meijer; Hilde Lapeere

doi:10.1111/cod.12886

Contact dermatitis caused by a new rubber compound detected in canvas shoes

Eva Hulstaert, Ola Bergendorff, Christina Persson, An Goossens, Liesbeth Gilissen, Malin Engfeldt, Magnus Bruze, Marie L Schuttelaar, Joost M Meijer, Hilde Lapeere

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.

OBJECTIVES: To identify the culprit allergen in the shoes.

METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.

RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.

CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.

Original language	English
Pages (from-to)	12-17
Number of pages	6
Journal	Contact Dermatitis
Volume	78
Issue number	1
Early online date	2017 Oct 17
DOIs	https://doi.org/10.1111/cod.12886
Publication status	Published - 2018 Jan 31

Subject classification (UKÄ)

Dermatology and Venereal Diseases

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Journal Article

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10.1111/cod.12886

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title = "Contact dermatitis caused by a new rubber compound detected in canvas shoes",

abstract = "BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.OBJECTIVES: To identify the culprit allergen in the shoes.METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.",

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author = "Eva Hulstaert and Ola Bergendorff and Christina Persson and An Goossens and Liesbeth Gilissen and Malin Engfeldt and Magnus Bruze and Schuttelaar, {Marie L} and Meijer, {Joost M} and Hilde Lapeere",

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doi = "10.1111/cod.12886",

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T1 - Contact dermatitis caused by a new rubber compound detected in canvas shoes

AU - Hulstaert, Eva

AU - Bergendorff, Ola

AU - Persson, Christina

AU - Goossens, An

AU - Gilissen, Liesbeth

AU - Engfeldt, Malin

AU - Bruze, Magnus

AU - Schuttelaar, Marie L

AU - Meijer, Joost M

AU - Lapeere, Hilde

PY - 2018/1/31

Y1 - 2018/1/31

N2 - BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.OBJECTIVES: To identify the culprit allergen in the shoes.METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.

AB - BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.OBJECTIVES: To identify the culprit allergen in the shoes.METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.

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DO - 10.1111/cod.12886

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C2 - 29044554

SN - 0105-1873

VL - 78

SP - 12

EP - 17

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Contact dermatitis caused by a new rubber compound detected in canvas shoes

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