Controlled short-linkage assembly of functional nano-objects

Shilpi Chaudhary, Tripta Kamra, Khan Mohammad Ahsan Uddin, Olesia Snezhkova, H. Surangi N. Jayawardena, Mingdi Yan, Lars Montelius, Joachim Schnadt, Lei Ye

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)


In this work, we report a method that allows the deterministic, photo-controlled covalent assembly of nanoparticles directly on surface. As a model system, we study the conjugation of molecularly imprinted polymer (MIP) nanoparticles on a glass surface and confirm that the immobilized nanoparticles maintain their molecular recognition functionality. The glass slide was first modified with perfluorophenylazide and then used to bind MIP nanoparticles under UV irradiation. After each step the surface was analyzed by water contact angle measurement, fluorescence microscopy, scanning electron microscopy, and/or synchrotron-based X-ray photoelectron spectroscopy. The MIP nanoparticles immobilized on the glass surface remained stable and maintained specific binding for the template molecule, propranolol. The method developed in this work allows MIP nanoparticles to be directly coupled to a flat surface, offering a straightforward means to construct robust chemical sensors. Using the reported photo conjugation method, it is possible to generate patterned assembly of nanoparticles using a photomask. Since perfluorophenylazide-based photochemistry works with all kinds of organic material, the method developed in this work is expected to enable immobilization of not only MIPs but also other kinds of organic and inorganic-organic core-shell particles for various applications involving photon or electron transfer. (C) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)22-28
JournalApplied Surface Science
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Atom and Molecular Physics and Optics
  • Biochemistry and Molecular Biology


  • Molecular imprinting
  • Nanoparticles
  • Photocoupling
  • X-ray photoelectron
  • spectroscopy
  • Immobilization


Dive into the research topics of 'Controlled short-linkage assembly of functional nano-objects'. Together they form a unique fingerprint.

Cite this