Wilms tumors in patients with constitutional WT1 mutations are examples of Knudson's tumor suppressor paradigm, with somatic inactivation of the second allele occurring through 11p loss of heterozygosity. The time point of this second hit has remained unknown. We analyzed seven Wilms tumors from two patients with constitutional WT1 mutations by whole exome sequencing and genomic array. All tumors exhibited wild type WT1 loss through uniparental isodisomy. Each tumor had a unique genomic breakpoint in 11p, typically accompanied by a private activating mutation of CTNNB1. Hence, convergent evolution rather than field carcinogenesis underlies multifocal tumors in WT1 mutation carriers.
|Journal||Pediatric Blood & Cancer|
|Publication status||Published - 2018 Nov 1|
Subject classification (UKÄ)
- Medical Genetics
- Cancer and Oncology
- convergent evolution
- Denys–Drash syndrome
- whole exome sequencing
- Wilms tumor
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Center for Translational Genomics
Ingrid Wilson (Manager)Department of Clinical Sciences, Lund