Convergent Synthesis of the Hexasaccharide Repeating Unit of the O-Antigenic OPS of Escherichia coli O133

Ankita Mitra, Balaram Mukhopadhyay

Research output: Contribution to journalArticlepeer-review

4 Citations (SciVal)

Abstract

Synthesis of the hexasaccharide repeating unit of the O-antigen from E. coli O133 has been accomplished with rational protecting group manipulations on commercially available monosaccharides and stereoselective glycosylations through a convergent protocol. A late stage TEMPO mediated oxidation is used to install the required uronic acid moiety. Chloroacetate group is used extensively as a temporary protecting group.

Original languageEnglish
Pages (from-to)4869-4878
Number of pages10
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number30
DOIs
Publication statusPublished - 2019 Aug 15

Subject classification (UKÄ)

  • Organic Chemistry

Keywords

  • Antigens
  • Glycosylation
  • Oxidation
  • Synthetic methods
  • Total synthesis

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