Correction for Residual Effects of B1+ Inhomogeniety on MT Saturation in FLASH-Based Multi-Parameter Mapping of the Brain

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Abstract

Maps of the MT-saturation as derived in FLASH-based multi-parameter mapping (MPM) are largely corrected for effects of flip angle inhomogeneity. Here, we present a heuristic model for residual effects of B1+ that is rooted in the dynamics of macromolecule saturation. Model parameters were validated for brain tissues by variation of the MT-pulse flip angle in an established MPM protocol. White and gray matter exhibited similar values. A post-hoc correction by an independent B1+ map yielded more symmetric MT maps and reduced variation across white matter.

Original languageEnglish
Title of host publicationProceedings of the International Society for Magnetic Resonance in Medicine Annual Meeting 2015
Place of PublicationBerkeley
PublisherInternational Society for Magnetic Resonance in Medicine
Pages3360
Number of pages1
Volume23
Publication statusPublished - 2015 May 30
EventISMRM 23rd Annual Meeting and Exhibition - Toronto, Canada
Duration: 2015 May 302015 Jun 5

Publication series

NameProceedings of the ISMRM
PublisherInternational Society for Magnetic Resonance in Medicine
Volume23
ISSN (Electronic)1545-4428

Conference

ConferenceISMRM 23rd Annual Meeting and Exhibition
Country/TerritoryCanada
CityToronto
Period2015/05/302015/06/05

Subject classification (UKÄ)

  • Engineering and Technology

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