CRITICAL LIMB ISCHAEMIA WITH SPECIAL EMPHASIS ON EPIDEMIOLOGY, INFLAMMATORY MARKERS AND CARDIAC FUNCTION

Jamal Barani

CRITICAL LIMB ISCHAEMIA WITH SPECIAL EMPHASIS ON EPIDEMIOLOGY, INFLAMMATORY MARKERS AND CARDIAC FUNCTION

Jamal Barani

Vascular Diseases - Clinical Research

Research output: Thesis › Doctoral Thesis (compilation)

Abstract

In Conclusion

Paper I. In patients undergoing aorto-iliac angiography, no effects of the procedure

were seen upon inflammatory mediators. On the other hand, angiography influenced

markers of platelet activation in these patients.

Paper II. The incidence of CLI in southern Sweden is 38/100 000 subjects/year.

Both medical risk factors for atherosclerosis and concomitant cardiovascular disease

are common among patients with CLI. Furthermore, medical risk-factor

treatment in these high-risk patients is suboptimal in relation to current recommendations.

Patients with CLI need to be evaluated and treated by physicians with

knowledge of and interest for treatment of risk factors for atherosclerosis.

Papers III-IV. Of Swedish CLI patients, 24 % die during the first year after

hospitalisation. Inflammatory markers, especially neopterin and TNF-?, independently

predict 1-year mortality in CLI, and are related to indices of cardiac dysfunction.

Paper V. Diabetes in CLI is often combined with renal impairment and more

often with infra-inguinal atherosclerosis. The inflammatory markers TNF-? and

neopterin are increased in diabetic patients with CLI as compared to non-diabetic

patients with CLI.

Original language	English
Qualification	Doctor
Awarding Institution	Department of Clinical Sciences, Malmö
Supervisors/Advisors	Gottsäter, Anders, Supervisor
Award date	2006 Jun 9
Publisher	Medicinsk Informationsteknik, Malmö
ISBN (Print)	91-85481-64-5
Publication status	Published - 2006

Bibliographical note

Defence details

Date: 2006-06-09
Time: 09:00
Place: Lilla Aulan vid Medicinskt forskingscentrum, ingång 59, Universitetssjukhuset MAS, Malmö

External reviewer(s)

Name: Björck, Martin
Title: Docent
Affiliation: Kärlkirurgisk kliniken, Akademiska Sjukhuset, Uppsala

---

<div class="article_info">J Barani, A Gottsäter, I Mattiasson and B Lindblad. <span class="article_issue_date">2002</span>. <span class="article_title">Platelet and leukocyte activation during aortoiliac angiography and angioplasty.</span> <span class="journal_series_title">Eur J Vasc Endovasc Surg</span>, <span class="journal_volume">vol 23</span> <span class="journal_pages">pp 220-225</span>.</div>
<div class="article_info">J Barani, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2005</span>. <span class="article_title">Suboptimal treatment of risk factors for atherosclerosis in critical limb ischaemia.</span> <span class="journal_series_title">24</span>, </div>
<div class="article_info">J Barani, JÅ Nilsson, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2005</span>. <span class="article_title">Inflammatory mediators are associated with 1-year mortality in critical limb ischaemia.</span> <span class="journal_series_title">42</span>, </div>
<div class="article_info">J Barani, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2006</span>. <span class="article_title">Cardiac function related to inflammatory mediators and one-year mortality in critical limb ischaemia.</span> <span class="journal_series_title">Angiology</span>, (inpress)</div>
<div class="article_info">L Bertz, J Barani, A Gottsäter, PM Nilsson, I Mattiasson and B Lindblad. <span class="article_issue_date"></span>. <span class="article_title">Inflammatory markers in patients with critical limb ischaemia: Differences between diabetic and non-diabetic patients.</span> (submitted)</div>

Subject classification (UKÄ)

Clinical Medicine

Free keywords

Risk factors.
Peripheral arterial disease.
Medicin (människa och djur)
Medicine (human and vertebrates)
Critical limb ischaemia.
inflammatory markers.
Mortality.
Congestive heart failure.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@phdthesis{66050af802874faa80c08990e3e937e4,

title = "CRITICAL LIMB ISCHAEMIA WITH SPECIAL EMPHASIS ON EPIDEMIOLOGY, INFLAMMATORY MARKERS AND CARDIAC FUNCTION",

abstract = "In Conclusion Paper I. In patients undergoing aorto-iliac angiography, no effects of the procedure were seen upon inflammatory mediators. On the other hand, angiography influenced markers of platelet activation in these patients. Paper II. The incidence of CLI in southern Sweden is 38/100 000 subjects/year. Both medical risk factors for atherosclerosis and concomitant cardiovascular disease are common among patients with CLI. Furthermore, medical risk-factor treatment in these high-risk patients is suboptimal in relation to current recommendations. Patients with CLI need to be evaluated and treated by physicians with knowledge of and interest for treatment of risk factors for atherosclerosis. Papers III-IV. Of Swedish CLI patients, 24 \% die during the first year after hospitalisation. Inflammatory markers, especially neopterin and TNF-?, independently predict 1-year mortality in CLI, and are related to indices of cardiac dysfunction. Paper V. Diabetes in CLI is often combined with renal impairment and more often with infra-inguinal atherosclerosis. The inflammatory markers TNF-? and neopterin are increased in diabetic patients with CLI as compared to non-diabetic patients with CLI.",

keywords = "Risk factors., Peripheral arterial disease., Medicin (m{\"a}nniska och djur), Medicine (human and vertebrates), Critical limb ischaemia., inflammatory markers., Mortality., Congestive heart failure.",

author = "Jamal Barani",

note = "Defence details Date: 2006-06-09 Time: 09:00 Place: Lilla Aulan vid Medicinskt forskingscentrum, ing{\aa}ng 59, Universitetssjukhuset MAS, Malm{\"o} External reviewer(s) Name: Bj{\"o}rck, Martin Title: Docent Affiliation: K{\"a}rlkirurgisk kliniken, Akademiska Sjukhuset, Uppsala --- <div class={"}article\_info{"}>J Barani, A Gotts{\"a}ter, I Mattiasson and B Lindblad. <span class={"}article\_issue\_date{"}>2002</span>. <span class={"}article\_title{"}>Platelet and leukocyte activation during aortoiliac angiography and angioplasty.</span> <span class={"}journal\_series\_title{"}>Eur J Vasc Endovasc Surg</span>, <span class={"}journal\_volume{"}>vol 23</span> <span class={"}journal\_pages{"}>pp 220-225</span>.</div> <div class={"}article\_info{"}>J Barani, I Mattiasson, B Lindblad and A Gotts{\"a}ter. <span class={"}article\_issue\_date{"}>2005</span>. <span class={"}article\_title{"}>Suboptimal treatment of risk factors for atherosclerosis in critical limb ischaemia.</span> <span class={"}journal\_series\_title{"}>24</span>, </div> <div class={"}article\_info{"}>J Barani, J{\AA} Nilsson, I Mattiasson, B Lindblad and A Gotts{\"a}ter. <span class={"}article\_issue\_date{"}>2005</span>. <span class={"}article\_title{"}>Inflammatory mediators are associated with 1-year mortality in critical limb ischaemia.</span> <span class={"}journal\_series\_title{"}>42</span>, </div> <div class={"}article\_info{"}>J Barani, I Mattiasson, B Lindblad and A Gotts{\"a}ter. <span class={"}article\_issue\_date{"}>2006</span>. <span class={"}article\_title{"}>Cardiac function related to inflammatory mediators and one-year mortality in critical limb ischaemia.</span> <span class={"}journal\_series\_title{"}>Angiology</span>, (inpress)</div> <div class={"}article\_info{"}>L Bertz, J Barani, A Gotts{\"a}ter, PM Nilsson, I Mattiasson and B Lindblad. <span class={"}article\_issue\_date{"}></span>. <span class={"}article\_title{"}>Inflammatory markers in patients with critical limb ischaemia: Differences between diabetic and non-diabetic patients.</span> (submitted)</div>",

year = "2006",

language = "English",

isbn = "91-85481-64-5",

publisher = "Medicinsk Informationsteknik, Malm{\"o}",

type = "Doctoral Thesis (compilation)",

school = "Department of Clinical Sciences, Malm{\"o}",

}

TY - THES

T1 - CRITICAL LIMB ISCHAEMIA WITH SPECIAL EMPHASIS ON EPIDEMIOLOGY, INFLAMMATORY MARKERS AND CARDIAC FUNCTION

AU - Barani, Jamal

N1 - Defence details Date: 2006-06-09 Time: 09:00 Place: Lilla Aulan vid Medicinskt forskingscentrum, ingång 59, Universitetssjukhuset MAS, Malmö External reviewer(s) Name: Björck, Martin Title: Docent Affiliation: Kärlkirurgisk kliniken, Akademiska Sjukhuset, Uppsala --- <div class="article_info">J Barani, A Gottsäter, I Mattiasson and B Lindblad. <span class="article_issue_date">2002</span>. <span class="article_title">Platelet and leukocyte activation during aortoiliac angiography and angioplasty.</span> <span class="journal_series_title">Eur J Vasc Endovasc Surg</span>, <span class="journal_volume">vol 23</span> <span class="journal_pages">pp 220-225</span>.</div> <div class="article_info">J Barani, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2005</span>. <span class="article_title">Suboptimal treatment of risk factors for atherosclerosis in critical limb ischaemia.</span> <span class="journal_series_title">24</span>, </div> <div class="article_info">J Barani, JÅ Nilsson, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2005</span>. <span class="article_title">Inflammatory mediators are associated with 1-year mortality in critical limb ischaemia.</span> <span class="journal_series_title">42</span>, </div> <div class="article_info">J Barani, I Mattiasson, B Lindblad and A Gottsäter. <span class="article_issue_date">2006</span>. <span class="article_title">Cardiac function related to inflammatory mediators and one-year mortality in critical limb ischaemia.</span> <span class="journal_series_title">Angiology</span>, (inpress)</div> <div class="article_info">L Bertz, J Barani, A Gottsäter, PM Nilsson, I Mattiasson and B Lindblad. <span class="article_issue_date"></span>. <span class="article_title">Inflammatory markers in patients with critical limb ischaemia: Differences between diabetic and non-diabetic patients.</span> (submitted)</div>

PY - 2006

Y1 - 2006

N2 - In Conclusion Paper I. In patients undergoing aorto-iliac angiography, no effects of the procedure were seen upon inflammatory mediators. On the other hand, angiography influenced markers of platelet activation in these patients. Paper II. The incidence of CLI in southern Sweden is 38/100 000 subjects/year. Both medical risk factors for atherosclerosis and concomitant cardiovascular disease are common among patients with CLI. Furthermore, medical risk-factor treatment in these high-risk patients is suboptimal in relation to current recommendations. Patients with CLI need to be evaluated and treated by physicians with knowledge of and interest for treatment of risk factors for atherosclerosis. Papers III-IV. Of Swedish CLI patients, 24 % die during the first year after hospitalisation. Inflammatory markers, especially neopterin and TNF-?, independently predict 1-year mortality in CLI, and are related to indices of cardiac dysfunction. Paper V. Diabetes in CLI is often combined with renal impairment and more often with infra-inguinal atherosclerosis. The inflammatory markers TNF-? and neopterin are increased in diabetic patients with CLI as compared to non-diabetic patients with CLI.

AB - In Conclusion Paper I. In patients undergoing aorto-iliac angiography, no effects of the procedure were seen upon inflammatory mediators. On the other hand, angiography influenced markers of platelet activation in these patients. Paper II. The incidence of CLI in southern Sweden is 38/100 000 subjects/year. Both medical risk factors for atherosclerosis and concomitant cardiovascular disease are common among patients with CLI. Furthermore, medical risk-factor treatment in these high-risk patients is suboptimal in relation to current recommendations. Patients with CLI need to be evaluated and treated by physicians with knowledge of and interest for treatment of risk factors for atherosclerosis. Papers III-IV. Of Swedish CLI patients, 24 % die during the first year after hospitalisation. Inflammatory markers, especially neopterin and TNF-?, independently predict 1-year mortality in CLI, and are related to indices of cardiac dysfunction. Paper V. Diabetes in CLI is often combined with renal impairment and more often with infra-inguinal atherosclerosis. The inflammatory markers TNF-? and neopterin are increased in diabetic patients with CLI as compared to non-diabetic patients with CLI.

KW - Risk factors.

KW - Peripheral arterial disease.

KW - Medicin (människa och djur)

KW - Medicine (human and vertebrates)

KW - Critical limb ischaemia.

KW - inflammatory markers.

KW - Mortality.

KW - Congestive heart failure.

M3 - Doctoral Thesis (compilation)

SN - 91-85481-64-5

PB - Medicinsk Informationsteknik, Malmö

ER -

CRITICAL LIMB ISCHAEMIA WITH SPECIAL EMPHASIS ON EPIDEMIOLOGY, INFLAMMATORY MARKERS AND CARDIAC FUNCTION

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

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Cite this