Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals

Ingrid Karlsson, Jeanette Linnea Tingstedt, Gülsen Özkaya Sahin, Mikkel Hansen, Zsofia Szojka, Marcus Buggert, Antonio Biague, Zacharias Da Silva, Fredrik Månsson, Joakim Esbjörnsson, Hans Norrgren, Patrik Medstrand, Anders Fomsgaard, Marianne Jansson, Sweden-Guinea-Bissau Cohort Research Group

Research output: Contribution to journalArticlepeer-review

6 Citations (SciVal)

Abstract

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.

Original languageEnglish
Pages (from-to)1749–1754
JournalThe Journal of infectious diseases
Volume219
Issue number11
Early online date2019 Feb 2
DOIs
Publication statusPublished - 2019

Subject classification (UKÄ)

  • Infectious Medicine
  • Immunology in the medical area

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