CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Tobias Skillbäck; Bahman Farahmand; Jonathan W Bartlett; Christoffer Rosén; Niklas Mattsson; Katarina Nägga; Lena Kilander; Dorota Religa; Anders Wimo; Bengt Winblad; Lars Rosengren; Jonathan M Schott; Kaj Blennow; Maria Eriksdotter; Henrik Zetterberg

doi:10.1212/WNL.0000000000001015

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Tobias Skillbäck, Bahman Farahmand, Jonathan W Bartlett, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Lars Rosengren, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg

Research output: Contribution to journal › Article › peer-review

Abstract

We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

Original language	English
Pages (from-to)	1945-1953
Journal	Neurology
Volume	83
Issue number	21
DOIs	https://doi.org/10.1212/WNL.0000000000001015
Publication status	Published - 2014

Subject classification (UKÄ)

Neurology

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10.1212/WNL.0000000000001015

http://www.ncbi.nlm.nih.gov/pubmed/25339208?dopt=Abstract

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Skillbäck, T., Farahmand, B., Bartlett, J. W., Rosén, C., Mattsson, N., Nägga, K., Kilander, L., Religa, D., Wimo, A., Winblad, B., Rosengren, L., Schott, J. M., Blennow, K., Eriksdotter, M., & Zetterberg, H. (2014). CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival. Neurology, 83(21), 1945-1953. https://doi.org/10.1212/WNL.0000000000001015

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title = "CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.",

abstract = "We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.",

author = "Tobias Skillb{\"a}ck and Bahman Farahmand and Bartlett, {Jonathan W} and Christoffer Ros{\'e}n and Niklas Mattsson and Katarina N{\"a}gga and Lena Kilander and Dorota Religa and Anders Wimo and Bengt Winblad and Lars Rosengren and Schott, {Jonathan M} and Kaj Blennow and Maria Eriksdotter and Henrik Zetterberg",

year = "2014",

doi = "10.1212/WNL.0000000000001015",

language = "English",

volume = "83",

pages = "1945--1953",

journal = "Neurology",

issn = "1526-632X",

publisher = "Lippincott Williams & Wilkins",

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Skillbäck, T, Farahmand, B, Bartlett, JW, Rosén, C, Mattsson, N, Nägga, K, Kilander, L, Religa, D, Wimo, A, Winblad, B, Rosengren, L, Schott, JM, Blennow, K, Eriksdotter, M & Zetterberg, H 2014, 'CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.', Neurology, vol. 83, no. 21, pp. 1945-1953. https://doi.org/10.1212/WNL.0000000000001015

TY - JOUR

T1 - CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

AU - Skillbäck, Tobias

AU - Farahmand, Bahman

AU - Bartlett, Jonathan W

AU - Rosén, Christoffer

AU - Mattsson, Niklas

AU - Nägga, Katarina

AU - Kilander, Lena

AU - Religa, Dorota

AU - Wimo, Anders

AU - Winblad, Bengt

AU - Rosengren, Lars

AU - Schott, Jonathan M

AU - Blennow, Kaj

AU - Eriksdotter, Maria

AU - Zetterberg, Henrik

PY - 2014

Y1 - 2014

N2 - We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

AB - We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

U2 - 10.1212/WNL.0000000000001015

DO - 10.1212/WNL.0000000000001015

M3 - Article

C2 - 25339208

SN - 1526-632X

VL - 83

SP - 1945

EP - 1953

JO - Neurology

JF - Neurology

IS - 21

ER -

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Abstract

Subject classification (UKÄ)

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