Cubic phase nanoparticles (Cubosome): Principles for controlling size, structure, and stability

Justas Barauskas, Markus Johnsson, F Joabsson, Fredrik Tiberg

Research output: Contribution to journalArticlepeer-review

225 Citations (SciVal)

Abstract

Methods and compositions for producing lipid-based cubic phase nanoparticles were first discovered in the 1990s. Since then a number of studies have been presented, but little is known about how to control key properties such as particle size, morphology, and stability of cubic phase dispersions. In the present work we give examples of how these properties can be tuned by composition and processing conditions. Importantly we show that stable particle dispersions with consistent size and structure can be produced by a simple processing scheme comprising a homogenization and heat treatment step.
Original languageEnglish
Pages (from-to)2569-2577
JournalLangmuir
Volume21
Issue number6
DOIs
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Physical Chemistry

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