Current progress of adhesins as vaccine candidates for Moraxella catarrhalis

Thuan Tong Tan, Kristian Riesbeck

Research output: Contribution to journalReview articlepeer-review

25 Citations (SciVal)

Abstract

Moraxello catorrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine candidates is discussed with a focus on various candidate antigens that spanned those discovered more than 10 years ago, for example, the ubiquitous surface proteins to newer antigens, such as the Moraxella IgD-binding hemagglutinin.
Original languageEnglish
Pages (from-to)949-956
JournalExpert Review of Vaccines
Volume6
Issue number6
DOIs
Publication statusPublished - 2007

Subject classification (UKÄ)

  • Microbiology in the medical area

Keywords

  • surface protein A1/A2
  • ubiquitous
  • outer membrane protein CD
  • OLpA
  • IgD binding protein/hag
  • Moraxella
  • Moraxella catarrhalis
  • mcmA
  • filamentous hemagglutinin
  • McaP

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