Cutaneous Human Papillomaviruses

Kristina Hazard

Cutaneous Human Papillomaviruses

Kristina Hazard

Clinical Microbiology, Malmö

Research output: Thesis › Doctoral Thesis (compilation)

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Abstract

Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of several HPV isolates representing putative subtypes have considerably extended the knowledge about this taxon.

Cutaneous HPVs are frequently found in healthy skin and some types have also been implicated in non-melanoma skin cancer in immunocompetent as well as in immunosuppressed individuals. However, data on whether these infections persist over time is limited. We recently reported that in a cohort of renal transplant recipients and matched healthy controls, 43% (19/44) of the cutaneous HPV infections persisted after 6.3 years. However, we did not detect any significant association between persistent infections and age, sex, immunosuppressive treatment, history of warts, or genus of HPV.

The heterogeneity of cutaneous HPVs, especially in the genus Beta-papillomavirus, has been extended through our characterisation of three new types, HPV93, 96, and 107.

The prevalence of these three types as well as HPV38 and its subtype HPV38b[FA125] and the recently described HPV92, was analysed in skin lesions and paired healthy skin. All types were only detected in low amounts and in low viral loads. However, the binding ability of the E7 protein of HPV92, 93 and 96 to the tumour suppressor protein Rb suggests a possible role for these types in the development of skin cancer.

Original language	English
Qualification	Doctor
Awarding Institution	Clinical Microbiology, Malmö
Supervisors/Advisors	Dillner, Joakim, Supervisor
Award date	2007 May 4
Publisher	Medical Microbiology, Lund University
ISBN (Print)	978-91-85559-58-9
Publication status	Published - 2007

Bibliographical note

Defence details

Date: 2007-05-04
Time: 09:15
Place: Pathology Lecture Hall Entrance 78 University Hospital Malmö

External reviewer(s)

Name: Pfister, Herbert
Title: Professor
Affiliation: Institute of Virology, University of Cologne, Cologne, Germany

---

<div class="article_info">K Hazard, A Karlsson, K Andersson, H Ekberg, J Dillner and O Forslund. <span class="article_issue_date">2007</span>. <span class="article_title">Cutaneous Human Papillomaviruses persist on healthy skin.</span> <span class="journal_series_title">Journal of Investigative Dermatology</span>, <span class="journal_volume">vol 127</span> <span class="journal_pages">pp 116-9</span>.</div>
<div class="article_info">K Hazard, L Eliasson, J Dillner and O Forslund. <span class="article_issue_date">2006</span>. <span class="article_title">Subtype HPV38b[FA125] demonstrates heterogeneity of Human Papillomavirus type 38.</span> <span class="journal_series_title">Int J Cancer</span>, <span class="journal_volume">vol 1;119</span> <span class="journal_pages">pp 1073-7</span>.</div>
<div class="article_info">K Hazard, K Andersson, J Dillner and O Forslund. <span class="article_issue_date"></span>. <span class="article_title">Human Papillomavirus subtypes are not uncommon.</span> <span class="journal_series_title">Virology</span>, (inpress)</div>
<div class="article_info">N Vasiljevic, K Hazard, L Eliasson, H Ly, A Hunziker, EM de Villiers, B Norrild, J Dillner and O Forslund. <span class="article_issue_date">2007</span>. <span class="article_title">Characterisation of two novel cutaneous Human Papillomaviruses, HPV93 and HPV96.</span> <span class="journal_series_title">Journal of General Virology</span>, <span class="journal_volume">vol 1;88</span> <span class="journal_pages">pp 1479-1483</span>.</div>
<div class="article_info">K Hazard, N Vasiljevic, J Dillner and O Forslund. <span class="article_issue_date"></span>. <span class="article_title">Isolation of a novel Beta-2 Human Papillomavirus from actinic keratosis.</span> (manuscript)</div>

Subject classification (UKÄ)

Microbiology in the medical area

Free keywords

Microbiology
bacteriology
virology
mycology
Skin cancer
HPV heterogeneity
Persistence
Human Papillomavirus
Phylogeny
Mikrobiologi
bakteriologi
virologi
mykologi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

@phdthesis{a7c8f479b9aa46739b083b4aac46a24c,

title = "Cutaneous Human Papillomaviruses",

abstract = "Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of several HPV isolates representing putative subtypes have considerably extended the knowledge about this taxon. Cutaneous HPVs are frequently found in healthy skin and some types have also been implicated in non-melanoma skin cancer in immunocompetent as well as in immunosuppressed individuals. However, data on whether these infections persist over time is limited. We recently reported that in a cohort of renal transplant recipients and matched healthy controls, 43% (19/44) of the cutaneous HPV infections persisted after 6.3 years. However, we did not detect any significant association between persistent infections and age, sex, immunosuppressive treatment, history of warts, or genus of HPV. The heterogeneity of cutaneous HPVs, especially in the genus Beta-papillomavirus, has been extended through our characterisation of three new types, HPV93, 96, and 107. The prevalence of these three types as well as HPV38 and its subtype HPV38b[FA125] and the recently described HPV92, was analysed in skin lesions and paired healthy skin. All types were only detected in low amounts and in low viral loads. However, the binding ability of the E7 protein of HPV92, 93 and 96 to the tumour suppressor protein Rb suggests a possible role for these types in the development of skin cancer.",

keywords = "Microbiology, bacteriology, virology, mycology, Skin cancer, HPV heterogeneity, Persistence, Human Papillomavirus, Phylogeny, Mikrobiologi, bakteriologi, virologi, mykologi",

author = "Kristina Hazard",

note = "Defence details Date: 2007-05-04 Time: 09:15 Place: Pathology Lecture Hall Entrance 78 University Hospital Malm{\"o} External reviewer(s) Name: Pfister, Herbert Title: Professor Affiliation: Institute of Virology, University of Cologne, Cologne, Germany --- <div class={"}article_info{"}>K Hazard, A Karlsson, K Andersson, H Ekberg, J Dillner and O Forslund. <span class={"}article_issue_date{"}>2007</span>. <span class={"}article_title{"}>Cutaneous Human Papillomaviruses persist on healthy skin.</span> <span class={"}journal_series_title{"}>Journal of Investigative Dermatology</span>, <span class={"}journal_volume{"}>vol 127</span> <span class={"}journal_pages{"}>pp 116-9</span>.</div> <div class={"}article_info{"}>K Hazard, L Eliasson, J Dillner and O Forslund. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Subtype HPV38b[FA125] demonstrates heterogeneity of Human Papillomavirus type 38.</span> <span class={"}journal_series_title{"}>Int J Cancer</span>, <span class={"}journal_volume{"}>vol 1;119</span> <span class={"}journal_pages{"}>pp 1073-7</span>.</div> <div class={"}article_info{"}>K Hazard, K Andersson, J Dillner and O Forslund. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Human Papillomavirus subtypes are not uncommon.</span> <span class={"}journal_series_title{"}>Virology</span>, (inpress)</div> <div class={"}article_info{"}>N Vasiljevic, K Hazard, L Eliasson, H Ly, A Hunziker, EM de Villiers, B Norrild, J Dillner and O Forslund. <span class={"}article_issue_date{"}>2007</span>. <span class={"}article_title{"}>Characterisation of two novel cutaneous Human Papillomaviruses, HPV93 and HPV96.</span> <span class={"}journal_series_title{"}>Journal of General Virology</span>, <span class={"}journal_volume{"}>vol 1;88</span> <span class={"}journal_pages{"}>pp 1479-1483</span>.</div> <div class={"}article_info{"}>K Hazard, N Vasiljevic, J Dillner and O Forslund. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Isolation of a novel Beta-2 Human Papillomavirus from actinic keratosis.</span> (manuscript)</div>",

year = "2007",

language = "English",

isbn = "978-91-85559-58-9",

publisher = "Medical Microbiology, Lund University",

type = "Doctoral Thesis (compilation)",

school = "Clinical Microbiology, Malm{\"o}",

}

TY - THES

T1 - Cutaneous Human Papillomaviruses

AU - Hazard, Kristina

N1 - Defence details Date: 2007-05-04 Time: 09:15 Place: Pathology Lecture Hall Entrance 78 University Hospital Malmö External reviewer(s) Name: Pfister, Herbert Title: Professor Affiliation: Institute of Virology, University of Cologne, Cologne, Germany --- <div class="article_info">K Hazard, A Karlsson, K Andersson, H Ekberg, J Dillner and O Forslund. <span class="article_issue_date">2007</span>. <span class="article_title">Cutaneous Human Papillomaviruses persist on healthy skin.</span> <span class="journal_series_title">Journal of Investigative Dermatology</span>, <span class="journal_volume">vol 127</span> <span class="journal_pages">pp 116-9</span>.</div> <div class="article_info">K Hazard, L Eliasson, J Dillner and O Forslund. <span class="article_issue_date">2006</span>. <span class="article_title">Subtype HPV38b[FA125] demonstrates heterogeneity of Human Papillomavirus type 38.</span> <span class="journal_series_title">Int J Cancer</span>, <span class="journal_volume">vol 1;119</span> <span class="journal_pages">pp 1073-7</span>.</div> <div class="article_info">K Hazard, K Andersson, J Dillner and O Forslund. <span class="article_issue_date"></span>. <span class="article_title">Human Papillomavirus subtypes are not uncommon.</span> <span class="journal_series_title">Virology</span>, (inpress)</div> <div class="article_info">N Vasiljevic, K Hazard, L Eliasson, H Ly, A Hunziker, EM de Villiers, B Norrild, J Dillner and O Forslund. <span class="article_issue_date">2007</span>. <span class="article_title">Characterisation of two novel cutaneous Human Papillomaviruses, HPV93 and HPV96.</span> <span class="journal_series_title">Journal of General Virology</span>, <span class="journal_volume">vol 1;88</span> <span class="journal_pages">pp 1479-1483</span>.</div> <div class="article_info">K Hazard, N Vasiljevic, J Dillner and O Forslund. <span class="article_issue_date"></span>. <span class="article_title">Isolation of a novel Beta-2 Human Papillomavirus from actinic keratosis.</span> (manuscript)</div>

PY - 2007

Y1 - 2007

N2 - Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of several HPV isolates representing putative subtypes have considerably extended the knowledge about this taxon. Cutaneous HPVs are frequently found in healthy skin and some types have also been implicated in non-melanoma skin cancer in immunocompetent as well as in immunosuppressed individuals. However, data on whether these infections persist over time is limited. We recently reported that in a cohort of renal transplant recipients and matched healthy controls, 43% (19/44) of the cutaneous HPV infections persisted after 6.3 years. However, we did not detect any significant association between persistent infections and age, sex, immunosuppressive treatment, history of warts, or genus of HPV. The heterogeneity of cutaneous HPVs, especially in the genus Beta-papillomavirus, has been extended through our characterisation of three new types, HPV93, 96, and 107. The prevalence of these three types as well as HPV38 and its subtype HPV38b[FA125] and the recently described HPV92, was analysed in skin lesions and paired healthy skin. All types were only detected in low amounts and in low viral loads. However, the binding ability of the E7 protein of HPV92, 93 and 96 to the tumour suppressor protein Rb suggests a possible role for these types in the development of skin cancer.

AB - Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of several HPV isolates representing putative subtypes have considerably extended the knowledge about this taxon. Cutaneous HPVs are frequently found in healthy skin and some types have also been implicated in non-melanoma skin cancer in immunocompetent as well as in immunosuppressed individuals. However, data on whether these infections persist over time is limited. We recently reported that in a cohort of renal transplant recipients and matched healthy controls, 43% (19/44) of the cutaneous HPV infections persisted after 6.3 years. However, we did not detect any significant association between persistent infections and age, sex, immunosuppressive treatment, history of warts, or genus of HPV. The heterogeneity of cutaneous HPVs, especially in the genus Beta-papillomavirus, has been extended through our characterisation of three new types, HPV93, 96, and 107. The prevalence of these three types as well as HPV38 and its subtype HPV38b[FA125] and the recently described HPV92, was analysed in skin lesions and paired healthy skin. All types were only detected in low amounts and in low viral loads. However, the binding ability of the E7 protein of HPV92, 93 and 96 to the tumour suppressor protein Rb suggests a possible role for these types in the development of skin cancer.

KW - Microbiology

KW - bacteriology

KW - virology

KW - mycology

KW - Skin cancer

KW - HPV heterogeneity

KW - Persistence

KW - Human Papillomavirus

KW - Phylogeny

KW - Mikrobiologi

KW - bakteriologi

KW - virologi

KW - mykologi

M3 - Doctoral Thesis (compilation)

SN - 978-91-85559-58-9

PB - Medical Microbiology, Lund University

ER -

Cutaneous Human Papillomaviruses

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Cite this