CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

Martin Augsten, Christina Hagglof, Eleonor Olsson, Claudia Stolz, Panagiotis Tsagozis, Tetyana Levchenko, Mitchell J. Frederick, Åke Borg, Patrick Micke, Lars Egevad, Arne Ostman

Research output: Contribution to journalArticlepeer-review


This study explored the role of secreted fibroblast-derived factors in prostate cancer growth. Analyses of matched normal and tumor tissue revealed up-regulation of CXCL14 in cancer-associated fibroblasts of a majority of prostate cancer. Fibroblasts overexpressing CXCL14 promoted the growth of prostate cancer xenografts, and increased tumor angiogenesis and macrophage infiltration. Mechanistic studies demonstrated that autocrine CXCL14-stimulation of fibroblasts stimulate migration and ERK-dependent proliferation of fibroblasts. CXCL14-stimulation of monocyte migration was also demonstrated. Furthermore, CXCL14-producing fibroblasts, but not recombinant CXCL14, enhanced in vitro proliferation and migration of prostate cancer cells and in vivo angiogenesis. These studies thus identify CXCL14 as a novel autocrine stimulator of fibroblast growth and migration, with multi-modal tumor-stimulatory activities. In more general terms, our findings suggest autocrine stimulation of fibroblasts as a previously unrecognized mechanism for chemokine-mediated stimulation of tumor growth, and suggest a novel mechanism whereby cancer-associated fibroblasts achieve their pro-tumorigenic phenotype.
Original languageEnglish
Pages (from-to)3414-3419
JournalProceedings of the National Academy of Sciences
Issue number9
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • cancer-associated fibroblasts
  • prostate cancer
  • tumor stroma


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