Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

Caroline Wigerup; Ingrid Øra; Cecilia Brunhoff; Lola Anagnostaki; Göran Landberg; Jenny L Persson

doi:10.1016/j.leukres.2005.07.010

Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

Caroline Wigerup, Ingrid Øra, Cecilia Brunhoff, Lola Anagnostaki, Göran Landberg, Jenny L Persson

Research output: Contribution to journal › Article › peer-review

Abstract

A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	254-261
Journal	Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2005.07.010
Publication status	Published - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology (Malmö) (013031000), Molecular Medicine (013031200)

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

cyclin A1
cyclin dependent kinase
event
acute lymphoblastic leukemia
free survival
cell cycle
disease characteristics

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10.1016/j.leukres.2005.07.010

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16182364&dopt=Abstract

Cite this

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title = "Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.",

abstract = "A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.",

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author = "Caroline Wigerup and Ingrid {\O}ra and Cecilia Brunhoff and Lola Anagnostaki and G{\"o}ran Landberg and Persson, {Jenny L}",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology (Malm{\"o}) (013031000), Molecular Medicine (013031200)",

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T1 - Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

AU - Wigerup, Caroline

AU - Øra, Ingrid

AU - Brunhoff, Cecilia

AU - Anagnostaki, Lola

AU - Landberg, Göran

AU - Persson, Jenny L

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology (Malmö) (013031000), Molecular Medicine (013031200)

PY - 2006

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N2 - A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.

AB - A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.

KW - cyclin A1

KW - cyclin dependent kinase

KW - event

KW - acute lymphoblastic leukemia

KW - free survival

KW - cell cycle

KW - disease characteristics

U2 - 10.1016/j.leukres.2005.07.010

DO - 10.1016/j.leukres.2005.07.010

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C2 - 16182364

SN - 1873-5835

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SP - 254

EP - 261

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

IS - 3

ER -

Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this