A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.
|Journal||Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis|
|Publication status||Published - 2006|
Bibliographical noteThe information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology (Malmö) (013031000), Molecular Medicine (013031200)
Subject classification (UKÄ)
- Cancer and Oncology
- cyclin A1
- cyclin dependent kinase
- acute lymphoblastic leukemia
- free survival
- cell cycle
- disease characteristics