Cystatin C as a Multifaceted Biomarker in Kidney Disease and Its Role in Defining "Shrunken Pore Syndrome"

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Abstract

Cystatin C, a basic nonglycosylated 13.3 kDa protein comprising a single polypeptide chain of 120 amino acid residues, is produced at a stable rate from a housekeeping gene in all nucleated cells and eliminated from the circulation by free filtration through the glomerular membranes as described in the first edition of "Biomarkers of Kidney Disease." This discourse will report some of the progress in the use of cystatin C as a multifaceted marker of kidney disease, which has occurred since then, including its role in identifying the novel syndrome called "Shrunken Pore Syndrome."

Original languageEnglish
Title of host publicationBiomarkers of Kidney Disease
EditorsC.L. Edelstein
PublisherElsevier
Pages225-240
Number of pages16
Edition2
ISBN (Print)9780128030141
DOIs
Publication statusPublished - 2017

Subject classification (UKÄ)

  • Clinical Laboratory Medicine

Free keywords

  • Biomarker
  • Creatinine
  • Cystatin C
  • GFR-estimating equations
  • Internal and external validation
  • Renal reserve
  • Shrunken Pore Syndrome

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