Cystatin C modulates cerebral beta-amyloidosis

Stephan A. Kaeser; Martin C. Herzig; Janaky Coomaraswamy; Ellen Kilger; Maj-Linda Selenica; David T. Winkler; Matthias Staufenbiel; Efrat Levy; Anders Grubb; Mathias Jucker

doi:10.1038/ng.2007.23

Cystatin C modulates cerebral beta-amyloidosis

Stephan A. Kaeser, Martin C. Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T. Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb, Mathias Jucker

Division of Clinical Chemistry and Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

Original language	English
Pages (from-to)	1437-1439
Journal	Nature Genetics
Volume	39
Issue number	12
DOIs	https://doi.org/10.1038/ng.2007.23
Publication status	Published - 2007

Subject classification (UKÄ)

Pharmacology and Toxicology
Medicinal Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.2007.23

Cite this

@article{321157a5f3cd486d93c692ba3f3b66b1,

title = "Cystatin C modulates cerebral beta-amyloidosis",

abstract = "The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.",

author = "Kaeser, {Stephan A.} and Herzig, {Martin C.} and Janaky Coomaraswamy and Ellen Kilger and Maj-Linda Selenica and Winkler, {David T.} and Matthias Staufenbiel and Efrat Levy and Anders Grubb and Mathias Jucker",

year = "2007",

doi = "10.1038/ng.2007.23",

language = "English",

volume = "39",

pages = "1437--1439",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Cystatin C modulates cerebral beta-amyloidosis

AU - Kaeser, Stephan A.

AU - Herzig, Martin C.

AU - Coomaraswamy, Janaky

AU - Kilger, Ellen

AU - Selenica, Maj-Linda

AU - Winkler, David T.

AU - Staufenbiel, Matthias

AU - Levy, Efrat

AU - Grubb, Anders

AU - Jucker, Mathias

PY - 2007

Y1 - 2007

N2 - The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

AB - The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

U2 - 10.1038/ng.2007.23

DO - 10.1038/ng.2007.23

M3 - Article

SN - 1546-1718

VL - 39

SP - 1437

EP - 1439

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Cystatin C modulates cerebral beta-amyloidosis

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this