Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction--a comparative study in rat and man

Ulf Malmqvist, Anders Arner, Bengt Uvelius

Research output: Contribution to journalArticlepeer-review

Abstract

Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bladder. In the human control detrusor the actin/myosin ratio was similar to that in the control rat. The isoform distribution of the myosin heavy chains differed between man and rat. In the biopsies from the patients with outlet obstruction and in the obstructed rat bladders the actin/myosin ratio was increased. A change in the myosin heavy chain distribution in the obstructed bladders was observed for both species. The filamin/actin ratio increased significantly in the obstructed rat bladders and tended to increase in the obstructed human bladders. Desmin was the dominating intermediate filament protein. The desmin/actin ratio increased in obstructed bladders in man and in rat.
Original languageEnglish
Pages (from-to)261-267
JournalScandinavian Journal of Urology and Nephrology
Volume25
Issue number4
DOIs
Publication statusPublished - 1991

Subject classification (UKÄ)

  • Medicinal Chemistry
  • Physiology
  • Pharmacology and Toxicology
  • Urology and Nephrology

Free keywords

  • myosin
  • actin
  • desmin
  • filamin
  • urinary bladder
  • detrusor
  • smooth muscle
  • human

Fingerprint

Dive into the research topics of 'Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction--a comparative study in rat and man'. Together they form a unique fingerprint.

Cite this