@inbook{830f7011e1f041bda8272b168a0f984a,
title = "D-serine influences synaptogenesis in a P19 cell model",
abstract = "Recently, d-serine has been identified as an important NMDA-receptor co-agonist, which might play a role in central nervous system development. We investigated this by studying rat P19 cells, an established model for neuronal and glial differentiation. Our results show that (1) the d-serine synthesizing enzyme serine racemase was expressed upon differentiation, (2) extracellular d-serine concentrations increased upon differentiation, which was inhibited by serine racemase antagonism, and (3) inhibition of d-serine synthesis or prevention of d-serine binding to the NMDA-receptor increased synaptophysin expression and intercellular connections, supporting a role for NMDA-receptor activation by d-serine, synthesized by serine racemase, in shaping synaptogenesis and neuronal circuitry during central nervous system development. In conjunction with recent evidence from literature, we therefore suggest that d-serine deficiency might be responsible for the severe neurological phenotype seen in patients with serine deficiency disorders. In addition, this may provide a pathophysiological mechanism for a role of d-serine deficiency in psychiatric disorders.",
keywords = "Central nervous system development, Glial fibrillary acidic protein, Neuronal circuitry, NMDAr activation, Serine racemase",
author = "Fuchs, {Sabine A.} and Roeleveld, {Martin W.} and Klomp, {Leo W.J.} and Ruud Berger and {de Koning}, {Tom J.}",
year = "2012",
month = jan,
day = "1",
doi = "10.1007/8904_2011_116",
language = "English",
series = "JIMD Reports",
publisher = "Springer Gabler",
pages = "47--53",
booktitle = "JIMD Reports",
address = "Germany",
}