Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

Cloé Domenighetti; Andreas Puschmann; Clara Hellberg; Alexis Elbaz; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium

doi:10.1002/mds.28902

Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

Cloé Domenighetti, Andreas Puschmann, Clara Hellberg, Alexis Elbaz, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).

CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

Original language	English
Pages (from-to)	857-864
Journal	Movement Disorders
Volume	37
Issue number	4
DOIs	https://doi.org/10.1002/mds.28902
Publication status	Published - 2022 Apr

Subject classification (UKÄ)

Neurology

Free keywords

Dairy Products/adverse effects
Female
Genetic Predisposition to Disease/genetics
Genome-Wide Association Study
Humans
Male
Mendelian Randomization Analysis
Parkinson Disease/epidemiology
Polymorphism, Single Nucleotide/genetics
Risk Factors

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10.1002/mds.28902

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title = "Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study",

abstract = "BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. {\textcopyright} 2022 International Parkinson and Movement Disorder Society.",

keywords = "Dairy Products/adverse effects, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis, Parkinson Disease/epidemiology, Polymorphism, Single Nucleotide/genetics, Risk Factors",

author = "Clo{\'e} Domenighetti and Andreas Puschmann and Clara Hellberg and Alexis Elbaz and {Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium}",

note = "{\textcopyright} 2022 International Parkinson and Movement Disorder Society.",

year = "2022",

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doi = "10.1002/mds.28902",

language = "English",

volume = "37",

pages = "857--864",

journal = "Movement Disorders",

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publisher = "John Wiley & Sons Inc.",

number = "4",

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T1 - Dairy Intake and Parkinson's Disease

T2 - A Mendelian Randomization Study

AU - Domenighetti, Cloé

AU - Puschmann, Andreas

AU - Hellberg, Clara

AU - Elbaz, Alexis

AU - Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

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KW - Genetic Predisposition to Disease/genetics

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Mendelian Randomization Analysis

KW - Parkinson Disease/epidemiology

KW - Polymorphism, Single Nucleotide/genetics

KW - Risk Factors

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DO - 10.1002/mds.28902

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JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

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Subject classification (UKÄ)

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