TY - JOUR
T1 - Dairy products, dietary calcium, and risk of inflammatory bowel disease
T2 - Results from a European prospective cohort investigation
AU - Opstelten, Jorrit L.
AU - Leenders, Max
AU - Dik, Vincent K.
AU - Chan, Simon S M
AU - Van Schaik, Fiona D M
AU - Khaw, Kay Tee
AU - Luben, Robert
AU - Hallmans, Göran
AU - Karling, Pontus
AU - Lindgren, Stefan
AU - Grip, Olof
AU - Key, Timothy J.
AU - Crowe, Francesca L.
AU - Boeing, Heiner
AU - Bergmann, Manuela M.
AU - Overvad, Kim
AU - Palli, Domenico
AU - Masala, Giovanna
AU - Racine, Antoine
AU - Carbonnel, Franck
AU - Boutron-Ruault, Marie Christine
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Andersen, Vibeke
AU - Kaaks, Rudolf
AU - Katzke, Verena A.
AU - Tumino, Rosario
AU - Trichopoulou, Antonia
AU - Siersema, Peter D.
AU - Bueno-De-Mesquita, H. Bas
AU - Hart, Andrew R.
AU - Oldenburg, Bas
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background: Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium, and the subsequent development of Crohn's disease (CD) and ulcerative colitis (UC). Methods: In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, and cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n 110) or UC (n 244) during follow-up were matched with 4 controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking. Results: Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI, 0.32-1.19, p trend 0.19) and 0.63 (95% CI, 0.28-1.42, p trend 0.23) for CD, and 0.80 (95% CI, 0.50-1.30, p trend 0.40) and 0.81 (95% CI, 0.49-1.34, p trend 0.60) for UC, respectively. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI, 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI, 0.49-1.47). Conclusions: Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect.
AB - Background: Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium, and the subsequent development of Crohn's disease (CD) and ulcerative colitis (UC). Methods: In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, and cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n 110) or UC (n 244) during follow-up were matched with 4 controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking. Results: Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI, 0.32-1.19, p trend 0.19) and 0.63 (95% CI, 0.28-1.42, p trend 0.23) for CD, and 0.80 (95% CI, 0.50-1.30, p trend 0.40) and 0.81 (95% CI, 0.49-1.34, p trend 0.60) for UC, respectively. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI, 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI, 0.49-1.47). Conclusions: Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect.
KW - calcium
KW - Crohn's disease
KW - dairy products
KW - etiology
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=84971001498&partnerID=8YFLogxK
U2 - 10.1097/MIB.0000000000000798
DO - 10.1097/MIB.0000000000000798
M3 - Article
C2 - 27120568
AN - SCOPUS:84971001498
VL - 22
SP - 1403
EP - 1411
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1536-4844
IS - 6
ER -