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Abstract
Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. Methods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. Results: Younger children lost more C-peptide (p < 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p < 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p < 0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p < 0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p < 0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. Conclusions/interpretation: Even in a restricted geographical area and narrow age range (< 18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 203-209 |
Journal | Diabetes Research and Clinical Practice |
Volume | 100 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2013 |
Subject classification (UKÄ)
- Endocrinology and Diabetes
Free keywords
- C-peptide
- Natural course
- Type 1 diabetes
- Children
- BMI
- Intervention
- trials
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BDD: Better Diabetes Diagnosis (BDD)
Carlsson, A. (PI), Lernmark, Å. (CoI), Elding Larsson, H. (CoI), Forsander, G. (Researcher), Ivarsson, S. (Researcher), Marcus, C. (Researcher), Ludvigsson, J. (CoI), Persson, M. (Researcher), Samuelsson, U. (Researcher), Åkesson, K. (Researcher) & Pundziute Lyckå, A. (Researcher)
Barndiabetesfonden, Diabetesfonden - Stiftelsen Svenska Diabetesförbundets Forskningsfond
2005/05/01 → …
Project: Research