Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Oliver Kluth; Mandy Stadion; Pascal Gottmann; Heja Aga; Markus Jähnert; Stephan Scherneck; Heike Vogel; Ulrika Krus; Anett Seelig; Charlotte Ling; Jantje Gerdes; Annette Schürmann

doi:10.1016/j.celrep.2019.02.056

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Oliver Kluth, Mandy Stadion, Pascal Gottmann, Heja Aga, Markus Jähnert, Stephan Scherneck, Heike Vogel, Ulrika Krus, Anett Seelig, Charlotte Ling, Jantje Gerdes, Annette Schürmann

Research output: Contribution to journal › Article › peer-review

Abstract

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Original language	English
Pages (from-to)	3027-3036.e3
Journal	Cell Reports
Volume	26
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.02.056
Publication status	Published - 2019

Subject classification (UKÄ)

Medical Genetics and Genomics (including Gene Therapy)
Endocrinology and Diabetes

Free keywords

beta-cell proliferation
cilia genes
human pancreatic islets
islet transcriptomics
New Zealand Obese mouse
pathway enrichment analysis
primary cilia
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2019.02.056

Cite this

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title = "Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans",

abstract = "Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.",

keywords = "beta-cell proliferation, cilia genes, human pancreatic islets, islet transcriptomics, New Zealand Obese mouse, pathway enrichment analysis, primary cilia, type 2 diabetes",

author = "Oliver Kluth and Mandy Stadion and Pascal Gottmann and Heja Aga and Markus J{\"a}hnert and Stephan Scherneck and Heike Vogel and Ulrika Krus and Anett Seelig and Charlotte Ling and Jantje Gerdes and Annette Sch{\"u}rmann",

year = "2019",

doi = "10.1016/j.celrep.2019.02.056",

language = "English",

volume = "26",

pages = "3027--3036.e3",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

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TY - JOUR

T1 - Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

AU - Kluth, Oliver

AU - Stadion, Mandy

AU - Gottmann, Pascal

AU - Aga, Heja

AU - Jähnert, Markus

AU - Scherneck, Stephan

AU - Vogel, Heike

AU - Krus, Ulrika

AU - Seelig, Anett

AU - Ling, Charlotte

AU - Gerdes, Jantje

AU - Schürmann, Annette

PY - 2019

Y1 - 2019

N2 - Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

AB - Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

KW - beta-cell proliferation

KW - cilia genes

KW - human pancreatic islets

KW - islet transcriptomics

KW - New Zealand Obese mouse

KW - pathway enrichment analysis

KW - primary cilia

KW - type 2 diabetes

U2 - 10.1016/j.celrep.2019.02.056

DO - 10.1016/j.celrep.2019.02.056

M3 - Article

C2 - 30865891

AN - SCOPUS:85062366876

SN - 2211-1247

VL - 26

SP - 3027-3036.e3

JO - Cell Reports

JF - Cell Reports

IS - 11

ER -

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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