Deepening ribosomal insights

Anders Liljas

doi:10.1021/cb600407u

Deepening ribosomal insights

Anders Liljas

Biochemistry and Structural Biology

Research output: Contribution to journal › Debate/Note/Editorial

Abstract

The remarkable progress of cryoelectron microscopy and crystallography in elucidating ribosomal structure and function continues. Most recently, two papers about complete 70S ribosomes from Thermus thermophilus at 2.8- and 3.7-angstrom resolution give us more details about the conformations of bound transfer RNA (tRNA) molecules; the bridges between subunits; the locations and roles of proteins, magnesium ions, and water molecules; and the dynamics of ribosomes. Very significant new insights have been gained, particularly for the tRNAs, which can only be studied in their entirety in full ribosomes.

Original language	English
Pages (from-to)	567-569
Journal	ACS Chemical Biology
Volume	1
Issue number	9
DOIs	https://doi.org/10.1021/cb600407u
Publication status	Published - 2006

Subject classification (UKÄ)

Biochemistry and Molecular Biology

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10.1021/cb600407u

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title = "Deepening ribosomal insights",

abstract = "The remarkable progress of cryoelectron microscopy and crystallography in elucidating ribosomal structure and function continues. Most recently, two papers about complete 70S ribosomes from Thermus thermophilus at 2.8- and 3.7-angstrom resolution give us more details about the conformations of bound transfer RNA (tRNA) molecules; the bridges between subunits; the locations and roles of proteins, magnesium ions, and water molecules; and the dynamics of ribosomes. Very significant new insights have been gained, particularly for the tRNAs, which can only be studied in their entirety in full ribosomes.",

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year = "2006",

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journal = "ACS Chemical Biology",

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publisher = "The American Chemical Society (ACS)",

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AB - The remarkable progress of cryoelectron microscopy and crystallography in elucidating ribosomal structure and function continues. Most recently, two papers about complete 70S ribosomes from Thermus thermophilus at 2.8- and 3.7-angstrom resolution give us more details about the conformations of bound transfer RNA (tRNA) molecules; the bridges between subunits; the locations and roles of proteins, magnesium ions, and water molecules; and the dynamics of ribosomes. Very significant new insights have been gained, particularly for the tRNAs, which can only be studied in their entirety in full ribosomes.

U2 - 10.1021/cb600407u

DO - 10.1021/cb600407u

M3 - Debate/Note/Editorial

SN - 1554-8937

VL - 1

SP - 567

EP - 569

JO - ACS Chemical Biology

JF - ACS Chemical Biology

IS - 9

ER -

Deepening ribosomal insights

Abstract

Subject classification (UKÄ)

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