Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis

Eva Julia, Xavier Montalban, Hanimad Al-zayat, Shohreh Issazadeh, Robert Goertsches, Roland Martin, Manuel Comabella

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)

Abstract

Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
Original languageEnglish
Pages (from-to)147-158
JournalJournal of Neuroimmunology
Volume180
Issue number1-2
DOIs
Publication statusPublished - 2006

Subject classification (UKÄ)

  • Neurology

Keywords

  • multiple sclerosis
  • T cells
  • apoptosis

Fingerprint

Dive into the research topics of 'Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis'. Together they form a unique fingerprint.

Cite this