Degradation of human secretory immunoglobulin A by Blastocystis

Manoj K Puthia, Aparna Vaithilingam, Jia Lu, Kevin S W Tan

Research output: Contribution to journalArticlepeer-review

Abstract

Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo.

Original languageEnglish
Pages (from-to)386-9
Number of pages4
JournalParasitology Research
Volume97
Issue number5
DOIs
Publication statusPublished - 2005 Nov
Externally publishedYes

Subject classification (UKÄ)

  • Microbiology in the medical area
  • Immunology in the medical area

Free keywords

  • Animals
  • Aspartic Acid Endopeptidases/metabolism
  • Blastocystis/enzymology
  • Blastocystis hominis/enzymology
  • Culture Media, Conditioned/metabolism
  • Cysteine Endopeptidases/metabolism
  • Humans
  • Immunoglobulin A, Secretory/metabolism
  • Rats

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