Abstract
Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo.
Original language | English |
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Pages (from-to) | 386-9 |
Number of pages | 4 |
Journal | Parasitology Research |
Volume | 97 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2005 Nov |
Externally published | Yes |
Subject classification (UKÄ)
- Microbiology in the Medical Area
- Immunology in the Medical Area (including Cell and Immunotherapy)
Free keywords
- Animals
- Aspartic Acid Endopeptidases/metabolism
- Blastocystis/enzymology
- Blastocystis hominis/enzymology
- Culture Media, Conditioned/metabolism
- Cysteine Endopeptidases/metabolism
- Humans
- Immunoglobulin A, Secretory/metabolism
- Rats