Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

Jonatan Leffler; Ljudmila Stojanovich; Yehuda Shoenfeld; Gordana Bogdanovic; Roger Hesselstrand; Anna Blom

Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

Jonatan Leffler, Ljudmila Stojanovich, Yehuda Shoenfeld, Gordana Bogdanovic, Roger Hesselstrand, Anna Blom

Research output: Contribution to journal › Article › peer-review

Abstract

A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.

Original language	English
Pages (from-to)	66-70
Journal	Clinical and Experimental Rheumatology
Volume	32
Issue number	1
Publication status	Published - 2014

Subject classification (UKÄ)

Rheumatology and Autoimmunity

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http://www.ncbi.nlm.nih.gov/pubmed/24295292?dopt=Abstract

Cite this

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title = "Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.",

abstract = "A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.",

author = "Jonatan Leffler and Ljudmila Stojanovich and Yehuda Shoenfeld and Gordana Bogdanovic and Roger Hesselstrand and Anna Blom",

year = "2014",

language = "English",

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T1 - Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

AU - Leffler, Jonatan

AU - Stojanovich, Ljudmila

AU - Shoenfeld, Yehuda

AU - Bogdanovic, Gordana

AU - Hesselstrand, Roger

AU - Blom, Anna

PY - 2014

Y1 - 2014

N2 - A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.

AB - A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.

M3 - Article

SN - 1593-098X

VL - 32

SP - 66

EP - 70

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 1

ER -

Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

Abstract

Subject classification (UKÄ)

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