Design and clinical evaluation of robust PID control of propofol anesthesia in children

Klaske van Heusden; Guy A. Dumont; Kristian Soltesz; Christian L. Petersen; Aryannah Umedaly; Nicholas West; J. Mark Ansermino

doi:10.1109/TCST.2013.2260543

Design and clinical evaluation of robust PID control of propofol anesthesia in children

Klaske van Heusden, Guy A. Dumont, Kristian Soltesz, Christian L. Petersen, Aryannah Umedaly, Nicholas West, J. Mark Ansermino

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Abstract

This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.

Original language	English
Pages (from-to)	491-501
Journal	IEEE Transactions on Control Systems Technology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1109/TCST.2013.2260543
Publication status	Published - 2014

Subject classification (UKÄ)

Control Engineering

Free keywords

anesthesia
robust control
clinical trials
PID control

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TCST.2013.2260543

soltesz14aAccepted author manuscript, 2.18 MB

Anesthesia in Closed Loop
Soltesz, K. (PI), Troeng, O. (Research student), Bagge Carlson, F. (Research student) & Cervin, A. (Researcher)
2011/01/01 → 2020/01/01
Project: Research
LCCC
Holmqvist, A. (Researcher), Andersson, N. (Researcher), Cervin, A. (Researcher), Mannesson, A. (Researcher), Gattami, A. (Researcher), Ghulchak, A. (Researcher), Papadopoulos, A. V. (Researcher), Rantzer, A. (Researcher), Robertsson, A. (Researcher), Sootla, A. (Researcher), THEORIN, A. (Researcher), Bernhardsson, B. (Researcher), Olofsson, B. (Researcher), Wittenmark, B. (Researcher), Grussler, C. (Researcher), Johnsson, C. (Researcher), MADJIDIAN, D. (Researcher), Johannesson, E. (Researcher), Magnusson, F. (Researcher), Ståhl, F. (Researcher), Como, G. (Researcher), Chasparis, G. (Researcher), Turesson, G. (Researcher), Dressler, I. (Researcher), Åkesson, J. (Researcher), Cho, J. H. (Researcher), Årzén, K.-E. (Researcher), Åström, K. J. (Researcher), Sou, K. C. (Researcher), Mårtensson, K. (Researcher), Berntorp, K. (Researcher), Soltesz, K. (Researcher), Lessard, L. (Researcher), Hast, M. (Researcher), Rönn, M. (Researcher), Ansbjerg Kjær, M. (Researcher), Maggio, M. (Researcher), Kristalny, M. (Researcher), Garpinger, O. (Researcher), From, P. J. (Researcher), Larsson, P.-O. (Researcher), Giselsson, P. (Researcher), Johansson, R. (Researcher), Hägglund, T. (Researcher), Vladimerou, V. (Researcher), Romero Segovia, V. (Researcher), Aurelius, A. (Researcher), Cedersjö, G. (Researcher), Bür, K. (Researcher), Dellkrantz, M. (Researcher), Du, M. (Researcher), Amani, P. (Researcher), Larsson, R. (Researcher), Tärneberg, W. (Research student), Li, Z. (Researcher), Yin, L. (Researcher), Tufvesson, F. (Researcher), Höst, S. (Researcher), Nilsson, B. (Researcher), Stenström, S. (Researcher), Andersson, J. A. (Researcher), Diehl, S. (Researcher), Dürango, J. (Researcher), Ghazaei Ardakani, M. (Researcher), Forsberg, P.-O. (Researcher), Bengtsson, F. (Researcher), Jörntell, H. (Researcher), Arévalo, C. (Researcher), Führer, C. (Researcher), Andersson, C. (Researcher), Mohammadi, F. (Researcher), Ödling, P. (Researcher), Andersson, M. (Researcher), Kihl, M. (Researcher) & Tunestål, P. (Researcher)
2008/07/01 → 2018/06/30
Project: Research

Cite this

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title = "Design and clinical evaluation of robust PID control of propofol anesthesia in children",

abstract = "This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.",

keywords = "anesthesia, robust control, clinical trials, PID control",

author = "{van Heusden}, Klaske and Dumont, {Guy A.} and Kristian Soltesz and Petersen, {Christian L.} and Aryannah Umedaly and Nicholas West and Ansermino, {J. Mark}",

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language = "English",

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pages = "491--501",

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T1 - Design and clinical evaluation of robust PID control of propofol anesthesia in children

AU - van Heusden, Klaske

AU - Dumont, Guy A.

AU - Soltesz, Kristian

AU - Petersen, Christian L.

AU - Umedaly, Aryannah

AU - West, Nicholas

AU - Ansermino, J. Mark

PY - 2014

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AB - This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.

KW - anesthesia

KW - robust control

KW - clinical trials

KW - PID control

U2 - 10.1109/TCST.2013.2260543

DO - 10.1109/TCST.2013.2260543

M3 - Article

SN - 1558-0865

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SP - 491

EP - 501

JO - IEEE Transactions on Control Systems Technology

JF - IEEE Transactions on Control Systems Technology

IS - 2

ER -

Design and clinical evaluation of robust PID control of propofol anesthesia in children

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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Anesthesia in Closed Loop

LCCC

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