Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

Ingegerd Ivanov Öfverholm; Anh Nhi Tran; Linda Olsson; Vasilios Zachariadis; Mats Heyman; Eva Rudd; Elisabeth Syk Lundberg; Magnus Nordenskjöld; Bertil Johansson; Ann Nordgren; Gisela Barbany

doi:10.3109/10428194.2015.1136740

Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

Ingegerd Ivanov Öfverholm, Anh Nhi Tran, Linda Olsson, Vasilios Zachariadis, Mats Heyman, Eva Rudd, Elisabeth Syk Lundberg, Magnus Nordenskjöld, Bertil Johansson, Ann Nordgren, Gisela Barbany

Division of Clinical Genetics

Research output: Contribution to journal › Article › peer-review

Abstract

To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p

Original language	English
Pages (from-to)	2161-2170
Number of pages	10
Journal	Leukemia & Lymphoma
Volume	57
Issue number	9
Early online date	2016 Apr 18
DOIs	https://doi.org/10.3109/10428194.2015.1136740
Publication status	Published - 2016

Subject classification (UKÄ)

Hematology
Medical Genetics

Keywords

B-Other
CNA
copy number
deletion
pediatric ALL

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10.3109/10428194.2015.1136740

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Ivanov Öfverholm, I., Tran, A. N., Olsson, L., Zachariadis, V., Heyman, M., Rudd, E., Syk Lundberg, E., Nordenskjöld, M., Johansson, B., Nordgren, A., & Barbany, G. (2016). Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia. Leukemia & Lymphoma, 57(9), 2161-2170. https://doi.org/10.3109/10428194.2015.1136740

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title = "Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia",

abstract = "To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p ",

keywords = "B-Other, CNA, copy number, deletion, pediatric ALL",

author = "{Ivanov {\"O}fverholm}, Ingegerd and Tran, {Anh Nhi} and Linda Olsson and Vasilios Zachariadis and Mats Heyman and Eva Rudd and {Syk Lundberg}, Elisabeth and Magnus Nordenskj{\"o}ld and Bertil Johansson and Ann Nordgren and Gisela Barbany",

year = "2016",

doi = "10.3109/10428194.2015.1136740",

language = "English",

volume = "57",

pages = "2161--2170",

journal = "Leukemia & Lymphoma",

issn = "1029-2403",

publisher = "Taylor & Francis",

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Ivanov Öfverholm, I, Tran, AN, Olsson, L, Zachariadis, V, Heyman, M, Rudd, E, Syk Lundberg, E, Nordenskjöld, M, Johansson, B, Nordgren, A & Barbany, G 2016, 'Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia', Leukemia & Lymphoma, vol. 57, no. 9, pp. 2161-2170. https://doi.org/10.3109/10428194.2015.1136740

TY - JOUR

T1 - Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

AU - Ivanov Öfverholm, Ingegerd

AU - Tran, Anh Nhi

AU - Olsson, Linda

AU - Zachariadis, Vasilios

AU - Heyman, Mats

AU - Rudd, Eva

AU - Syk Lundberg, Elisabeth

AU - Nordenskjöld, Magnus

AU - Johansson, Bertil

AU - Nordgren, Ann

AU - Barbany, Gisela

PY - 2016

Y1 - 2016

N2 - To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p

AB - To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p

KW - B-Other

KW - CNA

KW - copy number

KW - deletion

KW - pediatric ALL

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U2 - 10.3109/10428194.2015.1136740

DO - 10.3109/10428194.2015.1136740

M3 - Article

C2 - 27090575

AN - SCOPUS:84963812828

VL - 57

SP - 2161

EP - 2170

JO - Leukemia & Lymphoma

JF - Leukemia & Lymphoma

SN - 1029-2403

IS - 9

ER -

Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

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Subject classification (UKÄ)

Keywords

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