Detection of pre-plaque amyloid aggregation using FTIR

Oxana Klementieva; Anders Engdahl; Mathilde Faideau; Katarina Willén; Per Uvdal; Gunnar Keppler Gouras

doi:10.1016/j.jalz.2014.05.1158

Detection of pre-plaque amyloid aggregation using FTIR

Oxana Klementieva, Anders Engdahl, Mathilde Faideau, Katarina Willén, Per Uvdal, Gunnar Keppler Gouras

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.

Original language	English
Journal	Alzheimer's and Dementia
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/j.jalz.2014.05.1158
Publication status	Published - 2014 Jul 1

Subject classification (UKÄ)

Neurosciences
Neurology
Accelerator Physics and Instrumentation

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10.1016/j.jalz.2014.05.1158

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title = "Detection of pre-plaque amyloid aggregation using FTIR",

abstract = "Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.",

author = "Oxana Klementieva and Anders Engdahl and Mathilde Faideau and Katarina Will{\'e}n and Per Uvdal and {Keppler Gouras}, Gunnar",

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AU - Engdahl, Anders

AU - Faideau, Mathilde

AU - Willén, Katarina

AU - Uvdal, Per

AU - Keppler Gouras, Gunnar

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.

AB - Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.

U2 - 10.1016/j.jalz.2014.05.1158

DO - 10.1016/j.jalz.2014.05.1158

M3 - Article

SN - 1552-5279

VL - 10

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 4

ER -

Detection of pre-plaque amyloid aggregation using FTIR

Abstract

Subject classification (UKÄ)

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