Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu, K A Krogh, M Granados, Jan Åke Jönsson, B Halling-Sorensen

Research output: Contribution to journalArticlepeer-review

34 Citations (SciVal)

Abstract

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.
Original languageEnglish
Pages (from-to)275-280
JournalJournal of Chromatography A
Volume1187
Issue number1-2
DOIs
Publication statusPublished - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

  • Analytical Chemistry

Keywords

  • ivermectin
  • hollow fibre-supported liquid membrane
  • LC-MS
  • surface
  • water
  • transformation products

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