Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu; K A Krogh; M Granados; Jan Åke Jönsson; B Halling-Sorensen

doi:10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu, K A Krogh, M Granados, Jan Åke Jönsson, B Halling-Sorensen

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

Original language	English
Pages (from-to)	275-280
Journal	Journal of Chromatography A
Volume	1187
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2008.02.063
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

Analytical Chemistry

Free keywords

ivermectin
hollow fibre-supported liquid membrane
LC-MS
surface
water
transformation products

Access to Document

10.1016/j.chroma.2008.02.063

Cite this

Raich-Montiu, J., Krogh, K. A., Granados, M., Jönsson, J. Å., & Halling-Sorensen, B. (2008). Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography A, 1187(1-2), 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

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title = "Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry",

abstract = "A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.",

keywords = "ivermectin, hollow fibre-supported liquid membrane, LC-MS, surface, water, transformation products",

author = "J Raich-Montiu and Krogh, {K A} and M Granados and J{\"o}nsson, {Jan {\AA}ke} and B Halling-Sorensen",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)",

year = "2008",

doi = "10.1016/j.chroma.2008.02.063",

language = "English",

volume = "1187",

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Raich-Montiu, J, Krogh, KA, Granados, M, Jönsson, JÅ & Halling-Sorensen, B 2008, 'Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry', Journal of Chromatography A, vol. 1187, no. 1-2, pp. 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. / Raich-Montiu, J; Krogh, K A; Granados, M et al.
In: Journal of Chromatography A, Vol. 1187, No. 1-2, 2008, p. 275-280.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

AU - Raich-Montiu, J

AU - Krogh, K A

AU - Granados, M

AU - Jönsson, Jan Åke

AU - Halling-Sorensen, B

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

PY - 2008

Y1 - 2008

N2 - A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

AB - A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

KW - ivermectin

KW - hollow fibre-supported liquid membrane

KW - LC-MS

KW - surface

KW - water

KW - transformation products

U2 - 10.1016/j.chroma.2008.02.063

DO - 10.1016/j.chroma.2008.02.063

M3 - Article

C2 - 18329655

SN - 0021-9673

VL - 1187

SP - 275

EP - 280

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 1-2

ER -

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this