Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu; K A Krogh; M Granados; Jan Åke Jönsson; B Halling-Sorensen

doi:10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu, K A Krogh, M Granados, Jan Åke Jönsson, B Halling-Sorensen

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

34 Citations (SciVal)

Abstract

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

Original language	English
Pages (from-to)	275-280
Journal	Journal of Chromatography A
Volume	1187
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2008.02.063
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

Analytical Chemistry

Keywords

ivermectin
hollow fibre-supported liquid membrane
LC-MS
surface
water
transformation products

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10.1016/j.chroma.2008.02.063

Cite this

Raich-Montiu, J., Krogh, K. A., Granados, M., Jönsson, J. Å., & Halling-Sorensen, B. (2008). Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography A, 1187(1-2), 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

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title = "Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry",

abstract = "A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.",

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note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)",

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Raich-Montiu, J, Krogh, KA, Granados, M, Jönsson, JÅ & Halling-Sorensen, B 2008, 'Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry', Journal of Chromatography A, vol. 1187, no. 1-2, pp. 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. / Raich-Montiu, J; Krogh, K A; Granados, M; Jönsson, Jan Åke; Halling-Sorensen, B.

In: Journal of Chromatography A, Vol. 1187, No. 1-2, 2008, p. 275-280.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

AU - Raich-Montiu, J

AU - Krogh, K A

AU - Granados, M

AU - Jönsson, Jan Åke

AU - Halling-Sorensen, B

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

PY - 2008

Y1 - 2008

N2 - A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

AB - A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

KW - ivermectin

KW - hollow fibre-supported liquid membrane

KW - LC-MS

KW - surface

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KW - transformation products

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DO - 10.1016/j.chroma.2008.02.063

M3 - Article

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VL - 1187

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JO - Journal of chromatography. A

JF - Journal of chromatography. A

SN - 0021-9673

IS - 1-2

ER -

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

Abstract

Bibliographical note

Subject classification (UKÄ)

Keywords

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