Determination of non-steroidal anti-inflammatory drugs in sewage sludge by direct hollow fiber supported liquid membrane extraction and liquid chromatography-mass spectrometry

Ester Sagrista, Estelle Larsson, Maryam Ezoddin, Manuela Hidalgo, Victoria Salvado, Jan Åke Jönsson

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58 Citations (SciVal)

Abstract

In this study, a three-phase hollow fiber liquid-phase microextraction (HF-LPME) method combined with liquid chromatography-mass spectrometry was developed for direct determination of four non-steroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in sewage sludge. The drugs were extracted from non-spiked and spiked slurry samples with different amounts of sludge into an organic phase and then back-extracted into an aqueous phase held in the lumen of the hollow fiber. High enrichment factors ranging from 2761 to 3254 in pure water were achieved. In sludge samples, repeatability and inter-clay precision were tested with relative standard deviation values between 10-18% and 7-15%, respectively. Average concentrations of 29 +/- 9, 138 +/- 2, 39 +/- 5 and 122 +/- 7 ng/g were determined in dried sludge from Kallby sewage treatment plant (Sweden) for ketoprofen, naproxen, diclofenac and ibuprofen, respectively. (C) 2010 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)6153-6158
JournalJournal of Chromatography A
Volume1217
Issue number40
DOIs
Publication statusPublished - 2010

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004), Department of Chemistry (011001220)

Subject classification (UKÄ)

  • Analytical Chemistry

Keywords

  • NSAIDs
  • Sewage sludge
  • Hollow fiber supported liquid membrane
  • HF-LPME

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