Abstract
After time-consuming and costly investigations, patients with neck metastases from an occult primary often receive unnecessarily large radiation volumes to treat a possible origin in the nasopharynx. In this study a colorimetric antisense Epstein-Barr early ribonucleoprotein 1 (EBER1) oligonucleotide probe specific for Epstein-Barr virus RNA was hybridized in situ to metastatic tissue obtained from 18 nasopharyngeal, 54 oral and pharyngeal, and 12 occult carcinomas derived from an unselected population. All 16 nonkeratinizing nasopharyngeal carcinomas (NPCs) were positive for EBER1. Both cases of keratinizing NPC and all 54 other metastases were negative. A single positive case of occult carcinoma indicated its origin from NPC. In retrospect, 7 patients with occult carcinoma had received unnecessary treatment with irradiation to the nasopharynx. Nasopharyngeal carcinoma appears to be a less common origin of occult carcinoma than previously considered. In the proper clinicopathologic co
| Original language | English |
|---|---|
| Pages (from-to) | 407-412 |
| Journal | Laryngoscope |
| Volume | 105 |
| Issue number | 4 |
| Publication status | Published - 1995 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Oncology, MV (013035000), Pathology, (Lund) (013030000), Obstetric, Gynaecological and Prenatal Ultrasound Research Unit (013242720)
Subject classification (UKÄ)
- Cancer and Oncology
