Development of a thermal micro-biosensor fabricated on a silicon chip

Bin Xie; Bengt Danielsson; Petronella Norberg; Fredrik Winquist; Ingemar Lundström

doi:10.1016/0925-4005(92)80043-W

Development of a thermal micro-biosensor fabricated on a silicon chip

Bin Xie, Bengt Danielsson, Petronella Norberg, Fredrik Winquist, Ingemar Lundström

Pure and Applied Biochemistry

Linköping University

Research output: Contribution to journal › Article › peer-review

Abstract

In order to develop a sensitive, versatile and inexpensive portable instrument, a calorimetric micro-biosensor was designed and fabricated by etching part of the flow system into a silicon wafer. The utility of the device was tested using the enzymes, catalase and penicillinase. This sensor showed good reproducibility and linearity up to 100 mM. The system also showed higher sensitivity than the conventional enzyme thermistor (ET) when identical sample volumes (20 μl) were applied. Finally, future prospects in this field are discussed.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Sensors and Actuators B: Chemical
Volume	6
Issue number	1-3
DOIs	https://doi.org/10.1016/0925-4005(92)80043-W
Publication status	Published - 1992 Jan

Subject classification (UKÄ)

Analytical Chemistry

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10.1016/0925-4005(92)80043-W

Cite this

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title = "Development of a thermal micro-biosensor fabricated on a silicon chip",

abstract = "In order to develop a sensitive, versatile and inexpensive portable instrument, a calorimetric micro-biosensor was designed and fabricated by etching part of the flow system into a silicon wafer. The utility of the device was tested using the enzymes, catalase and penicillinase. This sensor showed good reproducibility and linearity up to 100 mM. The system also showed higher sensitivity than the conventional enzyme thermistor (ET) when identical sample volumes (20 μl) were applied. Finally, future prospects in this field are discussed.",

author = "Bin Xie and Bengt Danielsson and Petronella Norberg and Fredrik Winquist and Ingemar Lundstr{\"o}m",

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AU - Norberg, Petronella

AU - Winquist, Fredrik

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PY - 1992/1

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AB - In order to develop a sensitive, versatile and inexpensive portable instrument, a calorimetric micro-biosensor was designed and fabricated by etching part of the flow system into a silicon wafer. The utility of the device was tested using the enzymes, catalase and penicillinase. This sensor showed good reproducibility and linearity up to 100 mM. The system also showed higher sensitivity than the conventional enzyme thermistor (ET) when identical sample volumes (20 μl) were applied. Finally, future prospects in this field are discussed.

U2 - 10.1016/0925-4005(92)80043-W

DO - 10.1016/0925-4005(92)80043-W

M3 - Article

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JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

IS - 1-3

ER -

Development of a thermal micro-biosensor fabricated on a silicon chip

Abstract

Subject classification (UKÄ)

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