Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson’s Disease

Jana Rajova

Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson’s Disease

Research output: Thesis › Doctoral Thesis (compilation)

28 Downloads (Pure)

Original language	English
Qualification	Doctor
Awarding Institution	Department of Experimental Medical Science
Supervisors/Advisors	Björklund, Tomas, Supervisor Parmar, Malin, Assistant supervisor Åkerblom, Malin, Assistant supervisor
Award date	2023 Oct 23
Place of Publication	Lund
Publisher	Lund University, Faculty of Medicine
ISBN (Print)	978-91-8021-464-3
Publication status	Published - 2023

Bibliographical note

Defence details
Date: 2023-10-23
Time: 09:00
Place: Segerfalksalen, BMC A10, Sölvegatan 17 i Lund. Zoom: https://lu-se.zoom.us/j/69867404603
External reviewer(s):
Name: Linnarsson, Sten
Title: professor
Affiliation: Karolinska Institute

Subject classification (UKÄ)

Cell and Molecular Biology

Free keywords

spatial transcriptomics
Parkinson’s Disease
tissue analysis
in situ sequencing
RCA
method development
pseudotime

Access to Document

Thesis Jana Rajova utan papersFinal published version, 155 MB

2 Article

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
Avallone, M., Pardo, J., Mergiya, T. F., Rajova, J., Räsänen, A., Davidsson, M., Åkerblom, M., Quintino, L., Kumar, D., Bramham, C. R. & Björklund, T., 2023 Jun 15, In: Frontiers in Molecular Neuroscience. 16, 1140785.
Research output: Contribution to journal › Article › peer-review

Open Access
Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo.
Rájová, J., Davidsson, M., Avallone, M., Hartnor, M., Aldrin-Kirk, P., Cardoso, T., Nolbrant, S., Mollbrink, A., Storm, P., Heuer, A., Parmar, M. & Björklund, T., 2023 Jun 8, In: Molecular Therapy - Methods and Clinical Development. 29, p. 381-394
Research output: Contribution to journal › Article › peer-review

Open Access

Cite this

@phdthesis{1eabbce847bd4293b4c02c0f814f681d,

title = "Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson{\textquoteright}s Disease",

keywords = "spatial transcriptomics, Parkinson{\textquoteright}s Disease, tissue analysis, in situ sequencing, RCA, method development, pseudotime",

author = "Jana Rajova",

note = "Defence details Date: 2023-10-23 Time: 09:00 Place: Segerfalksalen, BMC A10, S{\"o}lvegatan 17 i Lund. Zoom: https://lu-se.zoom.us/j/69867404603 External reviewer(s): Name: Linnarsson, Sten Title: professor Affiliation: Karolinska Institute",

year = "2023",

language = "English",

isbn = "978-91-8021-464-3",

series = "Lund University, Faculty of Medicine Doctoral Dissertation Series",

publisher = "Lund University, Faculty of Medicine",

number = "2023:123",

type = "Doctoral Thesis (compilation)",

school = "Department of Experimental Medical Science",

}

TY - THES

T1 - Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson’s Disease

AU - Rajova, Jana

N1 - Defence details Date: 2023-10-23 Time: 09:00 Place: Segerfalksalen, BMC A10, Sölvegatan 17 i Lund. Zoom: https://lu-se.zoom.us/j/69867404603 External reviewer(s): Name: Linnarsson, Sten Title: professor Affiliation: Karolinska Institute

PY - 2023

Y1 - 2023

KW - spatial transcriptomics

KW - Parkinson’s Disease

KW - tissue analysis

KW - in situ sequencing

KW - RCA

KW - method development

KW - pseudotime

M3 - Doctoral Thesis (compilation)

SN - 978-91-8021-464-3

T3 - Lund University, Faculty of Medicine Doctoral Dissertation Series

PB - Lund University, Faculty of Medicine

CY - Lund

ER -

Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson’s Disease

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

Research output

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo.

Cite this