Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition

Sabina Sieri; Vittorio Krogh; Pietro Ferrari; Franco Berrino; Valeria Pala; Anne C. M. Thiebaut; Anne Tjonneland; Anja Olsen; Kim Overvad; Marianne Uhre Jakobsen; Francoise Clavel-Chapelon; Veronique Chajes; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Jakob Linseisen; Heiner Boeing; Ute Noethlings; Antonia Trichopoulou; Androniki Naska; Pagona Lagiou; Salvatore Panico; Domenico Palli; Paolo Vineis; Rosario Tumino; Eiliv Lund; Merethe Kumle; Guri Skeie; Carlos A. Gonzalez; Eva Ardanaz; Pilar Amiano; Maria Jose Tormo; Carmen Martinez-Garcia; Jose R. Quiros; Göran Berglund; Bo Gullberg; Goeran Hallmans; Per Lenner; H. Bas Bueno-de-Mesquita; Fraenzel J. B. van Duijnhoven; Petra H. M. Peeters; Carla H. van Gils; Timothy J. Key; Francesca L. Crowe; Sheila Bingham; Kay Tee Khaw; Sabina Rinaldi; Nadia Slimani; Mazda Jenab; Teresa Norat; Elio Riboli

doi:10.3945/ajcn.2008.26090

Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition

Sabina Sieri, Vittorio Krogh, Pietro Ferrari, Franco Berrino, Valeria Pala, Anne C. M. Thiebaut, Anne Tjonneland, Anja Olsen, Kim Overvad, Marianne Uhre Jakobsen, Francoise Clavel-Chapelon, Veronique Chajes, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Jakob Linseisen, Heiner Boeing, Ute Noethlings, Antonia Trichopoulou, Androniki Naska, Pagona LagiouSalvatore Panico, Domenico Palli, Paolo Vineis, Rosario Tumino, Eiliv Lund, Merethe Kumle, Guri Skeie, Carlos A. Gonzalez, Eva Ardanaz, Pilar Amiano, Maria Jose Tormo, Carmen Martinez-Garcia, Jose R. Quiros, Göran Berglund, Bo Gullberg, Goeran Hallmans, Per Lenner, H. Bas Bueno-de-Mesquita, Fraenzel J. B. van Duijnhoven, Petra H. M. Peeters, Carla H. van Gils, Timothy J. Key, Francesca L. Crowe, Sheila Bingham, Kay Tee Khaw, Sabina Rinaldi, Nadia Slimani, Mazda Jenab, Teresa Norat, Elio Riboli

Internal Medicine - Epidemiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12.

Original language	English
Pages (from-to)	1304-1312
Journal	American Journal of Clinical Nutrition
Volume	88
Issue number	5
DOIs	https://doi.org/10.3945/ajcn.2008.26090
Publication status	Published - 2008

Subject classification (UKÄ)

Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3945/ajcn.2008.26090

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Sieri, S., Krogh, V., Ferrari, P., Berrino, F., Pala, V., Thiebaut, A. C. M., Tjonneland, A., Olsen, A., Overvad, K., Jakobsen, M. U., Clavel-Chapelon, F., Chajes, V., Boutron-Ruault, M.-C., Kaaks, R., Linseisen, J., Boeing, H., Noethlings, U., Trichopoulou, A., Naska, A., ... Riboli, E. (2008). Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition, 88(5), 1304-1312. https://doi.org/10.3945/ajcn.2008.26090

@article{69ded9c93cd9499bbbd1ac63e2fa9b9c,

title = "Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12.",

author = "Sabina Sieri and Vittorio Krogh and Pietro Ferrari and Franco Berrino and Valeria Pala and Thiebaut, {Anne C. M.} and Anne Tjonneland and Anja Olsen and Kim Overvad and Jakobsen, {Marianne Uhre} and Francoise Clavel-Chapelon and Veronique Chajes and Marie-Christine Boutron-Ruault and Rudolf Kaaks and Jakob Linseisen and Heiner Boeing and Ute Noethlings and Antonia Trichopoulou and Androniki Naska and Pagona Lagiou and Salvatore Panico and Domenico Palli and Paolo Vineis and Rosario Tumino and Eiliv Lund and Merethe Kumle and Guri Skeie and Gonzalez, {Carlos A.} and Eva Ardanaz and Pilar Amiano and Tormo, {Maria Jose} and Carmen Martinez-Garcia and Quiros, {Jose R.} and G{\"o}ran Berglund and Bo Gullberg and Goeran Hallmans and Per Lenner and Bueno-de-Mesquita, {H. Bas} and {van Duijnhoven}, {Fraenzel J. B.} and Peeters, {Petra H. M.} and {van Gils}, {Carla H.} and Key, {Timothy J.} and Crowe, {Francesca L.} and Sheila Bingham and Khaw, {Kay Tee} and Sabina Rinaldi and Nadia Slimani and Mazda Jenab and Teresa Norat and Elio Riboli",

year = "2008",

doi = "10.3945/ajcn.2008.26090",

language = "English",

volume = "88",

pages = "1304--1312",

journal = "American Journal of Clinical Nutrition",

issn = "1938-3207",

publisher = "Elsevier",

number = "5",

}

Sieri, S, Krogh, V, Ferrari, P, Berrino, F, Pala, V, Thiebaut, ACM, Tjonneland, A, Olsen, A, Overvad, K, Jakobsen, MU, Clavel-Chapelon, F, Chajes, V, Boutron-Ruault, M-C, Kaaks, R, Linseisen, J, Boeing, H, Noethlings, U, Trichopoulou, A, Naska, A, Lagiou, P, Panico, S, Palli, D, Vineis, P, Tumino, R, Lund, E, Kumle, M, Skeie, G, Gonzalez, CA, Ardanaz, E, Amiano, P, Tormo, MJ, Martinez-Garcia, C, Quiros, JR, Berglund, G, Gullberg, B, Hallmans, G, Lenner, P, Bueno-de-Mesquita, HB, van Duijnhoven, FJB, Peeters, PHM, van Gils, CH, Key, TJ, Crowe, FL, Bingham, S, Khaw, KT, Rinaldi, S, Slimani, N, Jenab, M, Norat, T & Riboli, E 2008, 'Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition', American Journal of Clinical Nutrition, vol. 88, no. 5, pp. 1304-1312. https://doi.org/10.3945/ajcn.2008.26090

TY - JOUR

T1 - Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition

AU - Sieri, Sabina

AU - Krogh, Vittorio

AU - Ferrari, Pietro

AU - Berrino, Franco

AU - Pala, Valeria

AU - Thiebaut, Anne C. M.

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Clavel-Chapelon, Francoise

AU - Chajes, Veronique

AU - Boutron-Ruault, Marie-Christine

AU - Kaaks, Rudolf

AU - Linseisen, Jakob

AU - Boeing, Heiner

AU - Noethlings, Ute

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Lagiou, Pagona

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Vineis, Paolo

AU - Tumino, Rosario

AU - Lund, Eiliv

AU - Kumle, Merethe

AU - Skeie, Guri

AU - Gonzalez, Carlos A.

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Tormo, Maria Jose

AU - Martinez-Garcia, Carmen

AU - Quiros, Jose R.

AU - Berglund, Göran

AU - Gullberg, Bo

AU - Hallmans, Goeran

AU - Lenner, Per

AU - Bueno-de-Mesquita, H. Bas

AU - van Duijnhoven, Fraenzel J. B.

AU - Peeters, Petra H. M.

AU - van Gils, Carla H.

AU - Key, Timothy J.

AU - Crowe, Francesca L.

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Riboli, Elio

PY - 2008

Y1 - 2008

N2 - Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12.

AB - Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12.

U2 - 10.3945/ajcn.2008.26090

DO - 10.3945/ajcn.2008.26090

M3 - Article

SN - 1938-3207

VL - 88

SP - 1304

EP - 1312

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 5

ER -

Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition

Abstract

Subject classification (UKÄ)

UN SDGs

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